ID   SPD10_HUMAN             Reviewed;         265 AA.
AC   P0DUX0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=Speedy protein E10 {ECO:0000305};
GN   Name=SPDYE10 {ECO:0000312|HGNC:HGNC:51506};
GN   Synonyms=SPDYE10P {ECO:0000312|HGNC:HGNC:51506};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC211491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DUX0; -.
DR   PeptideAtlas; P0DUX0; -.
DR   Ensembl; ENST00000682856.2; ENSP00000509062.1; ENSG00000274570.6.
DR   Ensembl; ENST00000691996.1; ENSP00000508934.1; ENSG00000274570.6.
DR   MANE-Select; ENST00000333385.11; ENSP00000498819.1; NM_001382525.2; NP_001369454.1.
DR   MANE-Select; ENST00000340073.9; ENSP00000498510.1; NM_001351349.3; NP_001338278.1.
DR   MANE-Select; ENST00000575125.6; ENSP00000498945.1; NM_001382554.3; NP_001369483.1.
DR   MANE-Select; ENST00000671986.3; ENSP00000501236.1; NM_001351351.3; NP_001338280.1.
DR   MANE-Select; ENST00000691996.1; ENSP00000508934.1; NM_001382505.2; NP_001369434.1.
DR   HGNC; HGNC:51506; SPDYE10.
DR   neXtProt; NX_P0DUX0; -.
DR   GeneTree; ENSGT00940000154173; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Speedy protein E10"
FT                   /id="PRO_0000453931"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  31441 MW;  BF4F3DD204B75202 CRC64;
     MGQILGKIMM SHQPQPQEER SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
     KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
     IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
     NIFYFLYEET RSHIPLLSEL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
     LEELEEIQAY DPEHWVWARD RAHLS