ID   SPD11_HUMAN             Reviewed;         265 AA.
AC   P0DTA3;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Putative speedy protein E11 {ECO:0000305};
GN   Name=SPDYE11 {ECO:0000312|HGNC:HGNC:51507};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   FUNCTION.
RX   PubMed=27789755; DOI=10.1177/1087057116676086;
RA   Rex E.B., Shukla N., Gu S., Bredt D., DiSepio D.;
RT   "A Genome-Wide Arrayed cDNA Screen to Identify Functional Modulators of
RT   alpha7 Nicotinic Acetylcholine Receptors.";
RL   SLAS Discovery 22:155-165(2017).
CC   -!- FUNCTION: Acts as a modulator of the nicotinic acetylcholine receptor
CC       alpha-7 (CHRNA7) activity. {ECO:0000269|PubMed:27789755}.
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC211476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001338278.1; NM_001351349.2.
DR   RefSeq; XP_006716273.1; XM_006716210.3.
DR   RefSeq; XP_006716275.1; XM_006716212.3.
DR   RefSeq; XP_006726497.1; XM_006726434.3.
DR   RefSeq; XP_016868377.1; XM_017012888.1.
DR   RefSeq; XP_016868422.1; XM_017012933.1.
DR   RefSeq; XP_016885939.1; XM_017030450.1.
DR   AlphaFoldDB; P0DTA3; -.
DR   SMR; P0DTA3; -.
DR   MassIVE; P0DTA3; -.
DR   Ensembl; ENST00000340073.9; ENSP00000498510.1; ENSG00000275976.6.
DR   GeneID; 100996746; -.
DR   KEGG; hsa:100996746; -.
DR   MANE-Select; ENST00000333385.11; ENSP00000498819.1; NM_001382525.2; NP_001369454.1.
DR   MANE-Select; ENST00000340073.9; ENSP00000498510.1; NM_001351349.3; NP_001338278.1.
DR   MANE-Select; ENST00000575125.6; ENSP00000498945.1; NM_001382554.3; NP_001369483.1.
DR   MANE-Select; ENST00000671986.3; ENSP00000501236.1; NM_001351351.3; NP_001338280.1.
DR   MANE-Select; ENST00000691996.1; ENSP00000508934.1; NM_001382505.2; NP_001369434.1.
DR   CTD; 100996746; -.
DR   GeneCards; SPDYE11; -.
DR   HGNC; HGNC:51507; SPDYE11.
DR   HPA; ENSG00000286228; Not detected.
DR   neXtProt; NX_P0DTA3; -.
DR   VEuPathDB; HostDB:ENSG00000186645; -.
DR   VEuPathDB; HostDB:ENSG00000262461; -.
DR   VEuPathDB; HostDB:ENSG00000273520; -.
DR   VEuPathDB; HostDB:ENSG00000286228; -.
DR   OMA; FPLANIC; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000286228; Expressed in stromal cell of endometrium and 13 other tissues.
DR   GO; GO:0030548; F:acetylcholine receptor regulator activity; IDA:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Putative speedy protein E11"
FT                   /id="PRO_0000448233"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  31441 MW;  BF4F3DD204B75202 CRC64;
     MGQILGKIMM SHQPQPQEER SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
     KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
     IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
     NIFYFLYEET RSHIPLLSEL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
     LEELEEIQAY DPEHWVWARD RAHLS