ID   SPD12_HUMAN             Reviewed;         265 AA.
AC   P0DUX1;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=Speedy protein E12 {ECO:0000305};
GN   Name=SPDYE12 {ECO:0000312|HGNC:HGNC:51508};
GN   Synonyms=SPDYE12P {ECO:0000312|HGNC:HGNC:51508};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR   EMBL; AC211424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DUX1; -.
DR   PeptideAtlas; P0DUX1; -.
DR   Ensembl; ENST00000618416.3; ENSP00000510197.1; ENSG00000184616.10.
DR   MANE-Select; ENST00000618416.5; ENSP00000510197.1; NM_001382555.2; NP_001369484.1.
DR   HGNC; HGNC:51508; SPDYE12.
DR   neXtProt; NX_P0DUX1; -.
DR   GeneTree; ENSGT00940000154173; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Speedy protein E12"
FT                   /id="PRO_0000453932"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  31482 MW;  8A4EEDD3B507CA97 CRC64;
     MGQILGKIMM SHQPQPQEEQ SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
     KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
     IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
     NIFYFLYEET RSHIPLLREL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
     LEELEEIQAY DPEHWVWARD RAHLS