ID   SPD16_HUMAN             Reviewed;         312 AA.
AC   A6NNV3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 3.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Putative speedy protein E16 {ECO:0000305};
GN   Name=SPDYE16 {ECO:0000312|HGNC:HGNC:51512};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC004980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS87513.1; -.
DR   RefSeq; XP_006716274.1; XM_006716211.3.
DR   RefSeq; XP_016868376.1; XM_017012887.1.
DR   AlphaFoldDB; A6NNV3; -.
DR   SMR; A6NNV3; -.
DR   BioGRID; 3194700; 2.
DR   iPTMnet; A6NNV3; -.
DR   PhosphoSitePlus; A6NNV3; -.
DR   BioMuta; SPDYE16; -.
DR   MassIVE; A6NNV3; -.
DR   PeptideAtlas; A6NNV3; -.
DR   PRIDE; A6NNV3; -.
DR   DNASU; 102723555; -.
DR   Ensembl; ENST00000633306.2; ENSP00000487772.2; ENSG00000185040.14.
DR   GeneID; 102723555; -.
DR   CTD; 102723555; -.
DR   GeneCards; SPDYE16; -.
DR   HGNC; HGNC:51512; SPDYE16.
DR   HPA; ENSG00000185040; Low tissue specificity.
DR   neXtProt; NX_A6NNV3; -.
DR   VEuPathDB; HostDB:ENSG00000185040; -.
DR   OrthoDB; 1480540at2759; -.
DR   PhylomeDB; A6NNV3; -.
DR   PathwayCommons; A6NNV3; -.
DR   BioGRID-ORCS; 102723555; 2 hits in 10 CRISPR screens.
DR   GenomeRNAi; 102723555; -.
DR   Pharos; A6NNV3; Tdark.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NNV3; protein.
DR   Bgee; ENSG00000185040; Expressed in sural nerve and 102 other tissues.
DR   ExpressionAtlas; A6NNV3; baseline and differential.
DR   Genevisible; A6NNV3; HS.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 1.
DR   Pfam; PF11357; Spy1; 2.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..312
FT                   /note="Putative speedy protein E16"
FT                   /id="PRO_0000341229"
FT   REGION          16..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  37499 MW;  A11152A05FD3493A CRC64;
     MQKHYTVAWF LYSAPGVDPS PPCRSLGWKR KKEWSDESEE EPEKELAPEP EETWVVEMLC
     GLKMKLKQQR VSPILPEHHK DFNSQLAPGV DPSPPHRSFC WKRKREWWDE SEESLEEEPR
     KVLAPEPEEI WVVEMLCGLK MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV
     SDKYLLAMVI AYFSRAGLPS WQYQRIHFFL ALYLANDMEE DDEDPKQNIF YFLYGKTRSR
     IPLVRNRRFQ LCRCMNPRAR KNRSQIALFQ KLRFQFFCSM SGRAWVSREE LEEIQAYDPE
     HWVWARDRAR LS