ID   SPD21_HUMAN             Reviewed;         402 AA.
AC   A0A494C086;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   03-AUG-2022, entry version 16.
DE   RecName: Full=Putative speedy protein E21 {ECO:0000305};
GN   Name=SPDYE21 {ECO:0000312|HGNC:HGNC:51517};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC006480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A494C086; -.
DR   SMR; A0A494C086; -.
DR   MassIVE; A0A494C086; -.
DR   PeptideAtlas; A0A494C086; -.
DR   Ensembl; ENST00000424157.4; ENSP00000498431.1; ENSG00000230358.6.
DR   MANE-Select; ENST00000424157.4; ENSP00000498431.1; NM_001382715.2; NP_001369644.1.
DR   GeneCards; SPDYE21; -.
DR   HGNC; HGNC:51517; SPDYE21.
DR   neXtProt; NX_A0A494C086; -.
DR   VEuPathDB; HostDB:ENSG00000230358; -.
DR   GeneTree; ENSGT00940000154173; -.
DR   OMA; QWESAVE; -.
DR   ChiTaRS; SPDYE21P; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000230358; Expressed in bone marrow and 90 other tissues.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Putative speedy protein E21"
FT                   /id="PRO_0000451616"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  48117 MW;  87631B462E90B7BB CRC64;
     MDRTETRFRK RGQITGKITT SRQLHPQNEQ SPQRSTSGYP LQEVVDDEVL GPSAPGVDPS
     PPCRSLGWKR KKEWSDESEE EPEKELAPEP EETWVVETLC GLKMKLKQQR VSPILPEHHK
     DFNSQLAPGV DPSPPHRSFC WKRKREWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
     MKLKRRRVLL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI VYFSRAGLPS
     WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYGKTRSR IPLLRKRWFQ LGRSMNPRAR
     KNRSRIPLLR KRRFQLGRSM NPRARKYRSR IPLVRKRRFQ LRRCMNPRAR KNRSQIVLFQ
     KLRFQFFCSM SGRAWVSPEE LEEIQAYDPE HWVWARDRAH LS