SPD2_CAEBR
ID SPD2_CAEBR Reviewed; 829 AA.
AC Q61DP2; A8XFC8;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Spindle-defective protein 2;
GN Name=spd-2 {ECO:0000312|WormBase:CBG12404};
GN ORFNames=CBG12404 {ECO:0000312|WormBase:CBG12404};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Required both for centrosome duplication and maturation.
CC Required for pericentriolar material (PCM) recruitment.
CC {ECO:0000250|UniProtKB:P91870}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:P91870}.
CC Note=Component of the centrosome. Localizes to the centriole throughout
CC the cell cycle and accumulates on the PCM during mitosis (By
CC similarity). Recruitment to the centrosome during prophase of the 1-
CC cell embryo is regulated by the cye-1/cdk-2 complex.
CC {ECO:0000250|UniProtKB:P91870}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE600913; CAP31389.1; -; Genomic_DNA.
DR RefSeq; XP_002639685.1; XM_002639639.1.
DR AlphaFoldDB; Q61DP2; -.
DR STRING; 6238.CBG12404; -.
DR PRIDE; Q61DP2; -.
DR EnsemblMetazoa; CBG12404.1; CBG12404.1; WBGene00033359.
DR GeneID; 8581678; -.
DR KEGG; cbr:CBG_12404; -.
DR CTD; 8581678; -.
DR WormBase; CBG12404; CBP17508; WBGene00033359; Cbr-spd-2.
DR eggNOG; ENOG502RT76; Eukaryota.
DR HOGENOM; CLU_341384_0_0_1; -.
DR InParanoid; Q61DP2; -.
DR OMA; CHYEKQP; -.
DR OrthoDB; 1078008at2759; -.
DR Proteomes; UP000008549; Chromosome I.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000242; C:pericentriolar material; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007099; P:centriole replication; IBA:GO_Central.
DR GO; GO:0090222; P:centrosome-templated microtubule nucleation; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:InterPro.
DR GO; GO:0040025; P:vulval development; IEA:EnsemblMetazoa.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039103; Spd-2/CEP192.
DR PANTHER; PTHR16029; PTHR16029; 2.
PE 3: Inferred from homology;
KW Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW Reference proteome.
FT CHAIN 1..829
FT /note="Spindle-defective protein 2"
FT /id="PRO_0000072111"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..332
FT /evidence="ECO:0000255"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 92996 MW; 402BF108CD60710B CRC64;
MNEDAPMDLV DDRFADQSIQ DEPVDDGESF YNEDVYVDCE EDEDDDVVPT SENFRLENRY
KPSLHTPREL PTIREENRED VRSNTSSRVN TRPPSVLSDK SNDISNMFGF QDGGRAIDQY
TDQFYSEGNR AERLFPEAGF LQNSPVRDKQ NSWEPSVCHY EKQPTPEVKN NSPGLVFANM
SSKKDVTRKQ ENVRPGKMMP EKVNDENEPK SRRFSPERNT FTTSPMNSTK YLEEKTSTPK
RPGGTNRLGT RGLPSFECST IYDISPQRTS GTPKTYESRH PTNAYTPNSA TTSDTVLSNR
TIGDNTVQNV LKGVDINLLT ALENARKKRD RPQVKPDFRL NSLPRGKLSS TQRPKSDDHS
SMTSIVSSST QNNTGYRKIQ EQRNSATSTD LTNSNTSNFT NNTSRVSTAK NDFSRSSRQR
NGFSDSSVST IIPNMNSMTT RDRDGRDSVS SVRTISRASS TMTVGGGNGH MTSGAPKPLR
FHVSRLGFGY VPIGETLTMQ LEVENTTDRP CKVNARLDSK ITCFKVLDNA TTMIDPKKAI
KVRVAFTPTS LGRYSLYLKA EVAEQNFTQK IPVWGWGGVS KIAPISARNL QPTSNSSEFA
MFVSDMKRIA FKLGNSGDRS GFALLTVYDS AMRQVPNSYV RFNPSNGIVI GKNYEKLIEI
RIDPSYHDHY GELTNNRTSS AMSTVSTASS MASLRRRVIA GSDFFVQVAW GVEGIRERLR
MLEMKHKRRQ MIDGLDFTSH PFTDEKCVVY PPPDAYPTIS DEDHDLFAAS YSNFYINIFS
SPDGLNAFRA ATVSADKFDN DATVLETSAF RHQTFVNDVT MVPRHTKLM
