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SPD2_CAEBR
ID   SPD2_CAEBR              Reviewed;         829 AA.
AC   Q61DP2; A8XFC8;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Spindle-defective protein 2;
GN   Name=spd-2 {ECO:0000312|WormBase:CBG12404};
GN   ORFNames=CBG12404 {ECO:0000312|WormBase:CBG12404};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required both for centrosome duplication and maturation.
CC       Required for pericentriolar material (PCM) recruitment.
CC       {ECO:0000250|UniProtKB:P91870}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:P91870}.
CC       Note=Component of the centrosome. Localizes to the centriole throughout
CC       the cell cycle and accumulates on the PCM during mitosis (By
CC       similarity). Recruitment to the centrosome during prophase of the 1-
CC       cell embryo is regulated by the cye-1/cdk-2 complex.
CC       {ECO:0000250|UniProtKB:P91870}.
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DR   EMBL; HE600913; CAP31389.1; -; Genomic_DNA.
DR   RefSeq; XP_002639685.1; XM_002639639.1.
DR   AlphaFoldDB; Q61DP2; -.
DR   STRING; 6238.CBG12404; -.
DR   PRIDE; Q61DP2; -.
DR   EnsemblMetazoa; CBG12404.1; CBG12404.1; WBGene00033359.
DR   GeneID; 8581678; -.
DR   KEGG; cbr:CBG_12404; -.
DR   CTD; 8581678; -.
DR   WormBase; CBG12404; CBP17508; WBGene00033359; Cbr-spd-2.
DR   eggNOG; ENOG502RT76; Eukaryota.
DR   HOGENOM; CLU_341384_0_0_1; -.
DR   InParanoid; Q61DP2; -.
DR   OMA; CHYEKQP; -.
DR   OrthoDB; 1078008at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000242; C:pericentriolar material; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007099; P:centriole replication; IBA:GO_Central.
DR   GO; GO:0090222; P:centrosome-templated microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR   GO; GO:0071539; P:protein localization to centrosome; IEA:InterPro.
DR   GO; GO:0040025; P:vulval development; IEA:EnsemblMetazoa.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR039103; Spd-2/CEP192.
DR   PANTHER; PTHR16029; PTHR16029; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; Developmental protein;
KW   Reference proteome.
FT   CHAIN           1..829
FT                   /note="Spindle-defective protein 2"
FT                   /id="PRO_0000072111"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          41..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          314..332
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   829 AA;  92996 MW;  402BF108CD60710B CRC64;
     MNEDAPMDLV DDRFADQSIQ DEPVDDGESF YNEDVYVDCE EDEDDDVVPT SENFRLENRY
     KPSLHTPREL PTIREENRED VRSNTSSRVN TRPPSVLSDK SNDISNMFGF QDGGRAIDQY
     TDQFYSEGNR AERLFPEAGF LQNSPVRDKQ NSWEPSVCHY EKQPTPEVKN NSPGLVFANM
     SSKKDVTRKQ ENVRPGKMMP EKVNDENEPK SRRFSPERNT FTTSPMNSTK YLEEKTSTPK
     RPGGTNRLGT RGLPSFECST IYDISPQRTS GTPKTYESRH PTNAYTPNSA TTSDTVLSNR
     TIGDNTVQNV LKGVDINLLT ALENARKKRD RPQVKPDFRL NSLPRGKLSS TQRPKSDDHS
     SMTSIVSSST QNNTGYRKIQ EQRNSATSTD LTNSNTSNFT NNTSRVSTAK NDFSRSSRQR
     NGFSDSSVST IIPNMNSMTT RDRDGRDSVS SVRTISRASS TMTVGGGNGH MTSGAPKPLR
     FHVSRLGFGY VPIGETLTMQ LEVENTTDRP CKVNARLDSK ITCFKVLDNA TTMIDPKKAI
     KVRVAFTPTS LGRYSLYLKA EVAEQNFTQK IPVWGWGGVS KIAPISARNL QPTSNSSEFA
     MFVSDMKRIA FKLGNSGDRS GFALLTVYDS AMRQVPNSYV RFNPSNGIVI GKNYEKLIEI
     RIDPSYHDHY GELTNNRTSS AMSTVSTASS MASLRRRVIA GSDFFVQVAW GVEGIRERLR
     MLEMKHKRRQ MIDGLDFTSH PFTDEKCVVY PPPDAYPTIS DEDHDLFAAS YSNFYINIFS
     SPDGLNAFRA ATVSADKFDN DATVLETSAF RHQTFVNDVT MVPRHTKLM
 
 
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