ID   SPD8_HUMAN              Reviewed;         265 AA.
AC   P0DUD1;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 1.
DT   03-AUG-2022, entry version 7.
DE   RecName: Full=Putative speedy protein E8 {ECO:0000305};
GN   Name=SPDYE8 {ECO:0000312|HGNC:HGNC:33771};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC211476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006716273.1; XM_006716210.3.
DR   RefSeq; XP_006716275.1; XM_006716212.3.
DR   RefSeq; XP_006726497.1; XM_006726434.3.
DR   RefSeq; XP_016868377.1; XM_017012888.1.
DR   RefSeq; XP_016868422.1; XM_017012933.1.
DR   RefSeq; XP_016885939.1; XM_017030450.1.
DR   AlphaFoldDB; P0DUD1; -.
DR   SMR; P0DUD1; -.
DR   MassIVE; P0DUD1; -.
DR   Ensembl; ENST00000333385.11; ENSP00000498819.1; ENSG00000273520.6.
DR   MANE-Select; ENST00000333385.11; ENSP00000498819.1; NM_001382525.2; NP_001369454.1.
DR   MANE-Select; ENST00000340073.9; ENSP00000498510.1; NM_001351349.3; NP_001338278.1.
DR   MANE-Select; ENST00000575125.6; ENSP00000498945.1; NM_001382554.3; NP_001369483.1.
DR   MANE-Select; ENST00000671986.3; ENSP00000501236.1; NM_001351351.3; NP_001338280.1.
DR   MANE-Select; ENST00000691996.1; ENSP00000508934.1; NM_001382505.2; NP_001369434.1.
DR   GeneCards; SPDYE8; -.
DR   HGNC; HGNC:33771; SPDYE8.
DR   neXtProt; NX_P0DUD1; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000273520; Expressed in stromal cell of endometrium and 13 other tissues.
DR   ExpressionAtlas; P0DUD1; baseline.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Putative speedy protein E8"
FT                   /id="PRO_0000451617"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  31441 MW;  BF4F3DD204B75202 CRC64;
     MGQILGKIMM SHQPQPQEER SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
     KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
     IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
     NIFYFLYEET RSHIPLLSEL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
     LEELEEIQAY DPEHWVWARD RAHLS