SPDE2_HUMAN
ID SPDE2_HUMAN Reviewed; 402 AA.
AC Q495Y8; B4DY11;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Speedy protein E2;
GN Name=SPDYE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q495Y8; Q15691: MAPRE1; NbExp=3; IntAct=EBI-10241662, EBI-1004115;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q495Y8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q495Y8-2; Sequence=VSP_039851;
CC -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR EMBL; AK302217; BAG63573.1; -; mRNA.
DR EMBL; AC093668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100973; AAI00974.1; -; mRNA.
DR CCDS; CCDS34716.2; -. [Q495Y8-1]
DR RefSeq; NP_001026789.2; NM_001031618.3. [Q495Y8-1]
DR RefSeq; XP_016867712.1; XM_017012223.1. [Q495Y8-1]
DR AlphaFoldDB; Q495Y8; -.
DR SMR; Q495Y8; -.
DR BioGRID; 137321; 4.
DR IntAct; Q495Y8; 1.
DR STRING; 9606.ENSP00000421686; -.
DR iPTMnet; Q495Y8; -.
DR PhosphoSitePlus; Q495Y8; -.
DR BioMuta; SPDYE2; -.
DR DMDM; 308153503; -.
DR MassIVE; Q495Y8; -.
DR PaxDb; Q495Y8; -.
DR PeptideAtlas; Q495Y8; -.
DR PRIDE; Q495Y8; -.
DR Antibodypedia; 76761; 5 antibodies from 5 providers.
DR DNASU; 441273; -.
DR Ensembl; ENST00000341656.5; ENSP00000342628.4; ENSG00000205238.11. [Q495Y8-2]
DR Ensembl; ENST00000507918.6; ENSP00000421686.1; ENSG00000205238.11. [Q495Y8-1]
DR Ensembl; ENST00000691607.1; ENSP00000509749.1; ENSG00000205238.11. [Q495Y8-1]
DR GeneID; 441273; -.
DR KEGG; hsa:441273; -.
DR MANE-Select; ENST00000691607.2; ENSP00000509749.1; NM_001396242.1; NP_001383171.1.
DR UCSC; uc011kkx.3; human. [Q495Y8-1]
DR CTD; 441273; -.
DR GeneCards; SPDYE2; -.
DR HGNC; HGNC:33841; SPDYE2.
DR HPA; ENSG00000205238; Tissue enhanced (brain, testis).
DR MIM; 617624; gene.
DR neXtProt; NX_Q495Y8; -.
DR OpenTargets; ENSG00000205238; -.
DR PharmGKB; PA164726233; -.
DR VEuPathDB; HostDB:ENSG00000205238; -.
DR eggNOG; ENOG502SSQN; Eukaryota.
DR GeneTree; ENSGT00940000154173; -.
DR HOGENOM; CLU_070353_0_0_1; -.
DR InParanoid; Q495Y8; -.
DR OMA; GKIMTSH; -.
DR OrthoDB; 1480540at2759; -.
DR PhylomeDB; Q495Y8; -.
DR TreeFam; TF329827; -.
DR PathwayCommons; Q495Y8; -.
DR SignaLink; Q495Y8; -.
DR BioGRID-ORCS; 441273; 235 hits in 528 CRISPR screens.
DR ChiTaRS; SPDYE2; human.
DR GenomeRNAi; 441273; -.
DR Pharos; Q495Y8; Tdark.
DR PRO; PR:Q495Y8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q495Y8; protein.
DR Bgee; ENSG00000205238; Expressed in sural nerve and 100 other tissues.
DR ExpressionAtlas; Q495Y8; baseline and differential.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR InterPro; IPR020984; Speedy.
DR PANTHER; PTHR31156; PTHR31156; 2.
DR Pfam; PF11357; Spy1; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..402
FT /note="Speedy protein E2"
FT /id="PRO_0000332292"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039851"
FT CONFLICT 130
FT /note="V -> L (in Ref. 1; BAG63573)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="P -> R (in Ref. 1; BAG63573 and 3; AAI00974)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 48300 MW; A3B1FEEA1A59A85D CRC64;
MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ
KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS
