SPDE3_HUMAN
ID SPDE3_HUMAN Reviewed; 549 AA.
AC A6NKU9; Q495Y9; Q6PHC4;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Speedy protein E3 {ECO:0000305};
GN Name=SPDYE3 {ECO:0000312|HGNC:HGNC:35462};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=22763696; DOI=10.1007/s00018-012-1050-1;
RA Chauhan S., Zheng X., Tan Y.Y., Tay B.H., Lim S., Venkatesh B., Kaldis P.;
RT "Evolution of the Cdk-activator Speedy/RINGO in vertebrates.";
RL Cell. Mol. Life Sci. 69:3835-3850(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NKU9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NKU9-2; Sequence=VSP_040737;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis and spleen.
CC {ECO:0000269|PubMed:22763696}.
CC -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR EMBL; AC005071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236956; EAL23843.1; -; Genomic_DNA.
DR EMBL; BC100972; AAI00973.1; -; mRNA.
DR EMBL; BC056606; AAH56606.1; -; mRNA.
DR CCDS; CCDS47658.2; -. [A6NKU9-1]
DR RefSeq; NP_001004351.3; NM_001004351.4. [A6NKU9-1]
DR AlphaFoldDB; A6NKU9; -.
DR SMR; A6NKU9; -.
DR BioGRID; 137320; 1.
DR STRING; 9606.ENSP00000329565; -.
DR iPTMnet; A6NKU9; -.
DR PhosphoSitePlus; A6NKU9; -.
DR BioMuta; SPDYE3; -.
DR EPD; A6NKU9; -.
DR MassIVE; A6NKU9; -.
DR PaxDb; A6NKU9; -.
DR PeptideAtlas; A6NKU9; -.
DR PRIDE; A6NKU9; -.
DR Antibodypedia; 54849; 82 antibodies from 13 providers.
DR DNASU; 441272; -.
DR Ensembl; ENST00000332397.6; ENSP00000329565.6; ENSG00000214300.7. [A6NKU9-1]
DR GeneID; 441272; -.
DR KEGG; hsa:441272; -.
DR MANE-Select; ENST00000332397.6; ENSP00000329565.6; NM_001004351.5; NP_001004351.3.
DR UCSC; uc022aij.1; human. [A6NKU9-1]
DR CTD; 441272; -.
DR GeneCards; SPDYE3; -.
DR HGNC; HGNC:35462; SPDYE3.
DR HPA; ENSG00000214300; Tissue enriched (testis).
DR MIM; 617625; gene.
DR neXtProt; NX_A6NKU9; -.
DR PharmGKB; PA164726234; -.
DR VEuPathDB; HostDB:ENSG00000214300; -.
DR eggNOG; ENOG502SSQN; Eukaryota.
DR GeneTree; ENSGT00940000154173; -.
DR HOGENOM; CLU_496022_0_0_1; -.
DR InParanoid; A6NKU9; -.
DR OrthoDB; 1480540at2759; -.
DR PhylomeDB; A6NKU9; -.
DR TreeFam; TF329827; -.
DR PathwayCommons; A6NKU9; -.
DR BioGRID-ORCS; 441272; 17 hits in 711 CRISPR screens.
DR ChiTaRS; SPDYE3; human.
DR GenomeRNAi; 441272; -.
DR Pharos; A6NKU9; Tdark.
DR PRO; PR:A6NKU9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A6NKU9; protein.
DR Bgee; ENSG00000214300; Expressed in bone marrow cell and 102 other tissues.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR InterPro; IPR020984; Speedy.
DR PANTHER; PTHR31156; PTHR31156; 3.
DR Pfam; PF11357; Spy1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..549
FT /note="Speedy protein E3"
FT /id="PRO_0000342336"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..377
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040737"
FT CONFLICT 414
FT /note="D -> G (in Ref. 2; AAH56606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 549 AA; 63895 MW; 13027DC7B487B8C1 CRC64;
MTSHQPQPQE EQSPQRSTSG YPLQEVVDDE VSGPSAPGVD PSPPRRSLGC KRKRECLDES
DDEPEKELAP EPEETWVAET LCGLKMKAKR RRVSLVLPEY YEAFNRLLAP GVDPSPPRRS
LGCKRKRECL DESDDEPEKE LAPEPEETWV AETLCGLKMK AKRRRVSLVL PEYYEAFNRL
LAPGVDPSPP RRSLGCKRKR ECLDESDDEP EKELAPEPEE TWVAETLCGL KMKAKRRRVS
LVLPEYYEAF NRLLAPGVDP SPPRRSLGCK RKRECLDESD DEPEKELAPE PEETWVAETL
CGLKMKAKRR RVSLVLPEYY EAFNRLLAPG VDPSPPRRSL GCKRKRECLD ESDDEPEKEL
APEPEETWVA ETLCGLKMKA KRRRVSLVLP EYYEAFNRLL EDPVIKRFLA WDKDLRVSDK
YLLAMVIAYF SRAGLPSWQY QRIHFFLALY LANDMEEDDE APKQKIFYFL YGKTHSHIPL
RPKHWFQLCR PMNPRARKNC SQIALFQKRR FQFFCSMRCR AWVSPEELEE IQAYDPEHWV
WARDRAHLS
