SPDE4_HUMAN
ID SPDE4_HUMAN Reviewed; 237 AA.
AC A6NLX3; B2RUZ6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Speedy protein E4 {ECO:0000305};
GN Name=SPDYE4 {ECO:0000312|HGNC:HGNC:35463};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22763696; DOI=10.1007/s00018-012-1050-1;
RA Chauhan S., Zheng X., Tan Y.Y., Tay B.H., Lim S., Venkatesh B., Kaldis P.;
RT "Evolution of the Cdk-activator Speedy/RINGO in vertebrates.";
RL Cell. Mol. Life Sci. 69:3835-3850(2012).
CC -!- INTERACTION:
CC A6NLX3; O60885: BRD4; NbExp=4; IntAct=EBI-12047907, EBI-723869;
CC A6NLX3; Q00526: CDK3; NbExp=3; IntAct=EBI-12047907, EBI-1245761;
CC A6NLX3; Q00535: CDK5; NbExp=4; IntAct=EBI-12047907, EBI-1041567;
CC A6NLX3; P61024: CKS1B; NbExp=6; IntAct=EBI-12047907, EBI-456371;
CC A6NLX3; P35557: GCK; NbExp=3; IntAct=EBI-12047907, EBI-709928;
CC A6NLX3; Q92917: GPKOW; NbExp=3; IntAct=EBI-12047907, EBI-746309;
CC A6NLX3; Q96A72: MAGOHB; NbExp=5; IntAct=EBI-12047907, EBI-746778;
CC A6NLX3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12047907, EBI-741158;
CC A6NLX3; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-12047907, EBI-2557649;
CC A6NLX3; P47897: QARS1; NbExp=3; IntAct=EBI-12047907, EBI-347462;
CC A6NLX3; Q9NVG8: TBC1D13; NbExp=3; IntAct=EBI-12047907, EBI-12264956;
CC A6NLX3; O75604: USP2; NbExp=3; IntAct=EBI-12047907, EBI-743272;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC {ECO:0000269|PubMed:22763696}.
CC -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR EMBL; AC009451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146949; AAI46950.1; -; mRNA.
DR EMBL; BC146966; AAI46967.1; -; mRNA.
DR CCDS; CCDS45609.1; -.
DR RefSeq; NP_001121548.1; NM_001128076.1.
DR RefSeq; XP_005256689.1; XM_005256632.4.
DR RefSeq; XP_005256690.1; XM_005256633.4.
DR AlphaFoldDB; A6NLX3; -.
DR SMR; A6NLX3; -.
DR BioGRID; 132645; 11.
DR IntAct; A6NLX3; 60.
DR STRING; 9606.ENSP00000329522; -.
DR iPTMnet; A6NLX3; -.
DR PhosphoSitePlus; A6NLX3; -.
DR BioMuta; SPDYE4; -.
DR MassIVE; A6NLX3; -.
DR PaxDb; A6NLX3; -.
DR PeptideAtlas; A6NLX3; -.
DR PRIDE; A6NLX3; -.
DR ProteomicsDB; 1497; -.
DR Antibodypedia; 6244; 8 antibodies from 7 providers.
DR DNASU; 388333; -.
DR Ensembl; ENST00000328794.10; ENSP00000329522.6; ENSG00000183318.12.
DR Ensembl; ENST00000688021.1; ENSP00000510287.1; ENSG00000183318.12.
DR Ensembl; ENST00000689094.1; ENSP00000509506.1; ENSG00000183318.12.
DR GeneID; 388333; -.
DR KEGG; hsa:388333; -.
DR MANE-Select; ENST00000689094.1; ENSP00000509506.1; NM_001394956.1; NP_001381885.1.
DR UCSC; uc010cnz.1; human.
DR CTD; 388333; -.
DR GeneCards; SPDYE4; -.
DR HGNC; HGNC:35463; SPDYE4.
DR HPA; ENSG00000183318; Tissue enriched (testis).
DR MIM; 617628; gene.
DR neXtProt; NX_A6NLX3; -.
DR PharmGKB; PA164726235; -.
DR VEuPathDB; HostDB:ENSG00000183318; -.
DR eggNOG; ENOG502SSQN; Eukaryota.
DR GeneTree; ENSGT00940000154173; -.
DR HOGENOM; CLU_070353_3_0_1; -.
DR InParanoid; A6NLX3; -.
DR OMA; LLCSMRW; -.
DR OrthoDB; 1480540at2759; -.
DR PhylomeDB; A6NLX3; -.
DR TreeFam; TF329827; -.
DR PathwayCommons; A6NLX3; -.
DR SignaLink; A6NLX3; -.
DR BioGRID-ORCS; 388333; 11 hits in 1058 CRISPR screens.
DR GenomeRNAi; 388333; -.
DR Pharos; A6NLX3; Tdark.
DR PRO; PR:A6NLX3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NLX3; protein.
DR Bgee; ENSG00000183318; Expressed in left testis and 55 other tissues.
DR ExpressionAtlas; A6NLX3; baseline and differential.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR InterPro; IPR020984; Speedy.
DR PANTHER; PTHR31156; PTHR31156; 1.
DR Pfam; PF11357; Spy1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..237
FT /note="Speedy protein E4"
FT /id="PRO_0000349195"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 237 AA; 27806 MW; FAE6F98061C6FCCF CRC64;
MASGQARPPF EEESPQPSTT VRSPEVVVDD EVPGPSAPWI DPSPQPQSLG LKRKSEWSDE
SEEELEEELE LERAPEPEDT WVVETLCGLK MKLKRKRASS VLPEHHEAFN RLLGDPVVQK
FLAWDKDLRV SDKYLLAMVI AYFSRAGLFS WQYQRIHFFL ALYLASDMEE DNQAPKQDIF
SFLYGKNYSQ RPLFHKLRYQ LLCSMRWRTW VSPEEMEEIQ AYDPEHWVWA RDRTLIS
