ID   SPDE5_HUMAN             Reviewed;         402 AA.
AC   A6NIY4; A0A096LPK5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Speedy protein E5;
GN   Name=SPDYE5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR   EMBL; AC211429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS78241.1; -.
DR   RefSeq; NP_001293070.1; NM_001306141.1.
DR   AlphaFoldDB; A6NIY4; -.
DR   SMR; A6NIY4; -.
DR   STRING; 9606.ENSP00000485398; -.
DR   PhosphoSitePlus; A6NIY4; -.
DR   BioMuta; SPDYE5; -.
DR   MassIVE; A6NIY4; -.
DR   PeptideAtlas; A6NIY4; -.
DR   PRIDE; A6NIY4; -.
DR   Antibodypedia; 74587; 49 antibodies from 7 providers.
DR   DNASU; 442590; -.
DR   Ensembl; ENST00000625065.4; ENSP00000485398.1; ENSG00000170092.15.
DR   GeneID; 442590; -.
DR   KEGG; hsa:442590; -.
DR   MANE-Select; ENST00000625065.4; ENSP00000485398.1; NM_001306141.4; NP_001293070.1.
DR   UCSC; uc064emj.1; human.
DR   CTD; 442590; -.
DR   GeneCards; SPDYE5; -.
DR   HGNC; HGNC:35464; SPDYE5.
DR   HPA; ENSG00000170092; Tissue enhanced (testis).
DR   neXtProt; NX_A6NIY4; -.
DR   OpenTargets; ENSG00000170092; -.
DR   PharmGKB; PA164726251; -.
DR   VEuPathDB; HostDB:ENSG00000170092; -.
DR   eggNOG; ENOG502SSQN; Eukaryota.
DR   GeneTree; ENSGT00940000154173; -.
DR   InParanoid; A6NIY4; -.
DR   OMA; VWERERH; -.
DR   OrthoDB; 1480540at2759; -.
DR   PhylomeDB; A6NIY4; -.
DR   PathwayCommons; A6NIY4; -.
DR   BioGRID-ORCS; 442590; 40 hits in 186 CRISPR screens.
DR   ChiTaRS; SPDYE5; human.
DR   GenomeRNAi; 442590; -.
DR   Pharos; A6NIY4; Tdark.
DR   PRO; PR:A6NIY4; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NIY4; protein.
DR   Bgee; ENSG00000170092; Expressed in sural nerve and 101 other tissues.
DR   ExpressionAtlas; A6NIY4; baseline and differential.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Speedy protein E5"
FT                   /id="PRO_0000328811"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  47997 MW;  F11F4279DCF6A4B5 CRC64;
     MDRTETRFRK RGQITEKITT SRQPQPQNEQ SPQRSTSGYP LQEVVDDEVL GPSAPGVDPS
     PPCRSLGWKR KREWSDESAE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
     GFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
     MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
     WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYGKNRSR IPLLRKRWFQ LGRSMNPRAR
     KKRSRIPLLR KRRFQLGRSM NPRARKNRSR IPLLRKRRFQ LGRSMNLRAR KNRSQIVLFQ
     KRRFQFFCSM SGRAWVSPEE LEEIQAYDPE HWVWARDRAH LS