ID   SPDE6_HUMAN             Reviewed;         402 AA.
AC   P0CI01; A0A096LNU6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Speedy protein E6;
GN   Name=SPDYE6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- INTERACTION:
CC       P0CI01; Q92624: APPBP2; NbExp=3; IntAct=EBI-11960469, EBI-743771;
CC       P0CI01; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11960469, EBI-11988175;
CC       P0CI01; Q15691: MAPRE1; NbExp=3; IntAct=EBI-11960469, EBI-1004115;
CC       P0CI01; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11960469, EBI-726739;
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR   EMBL; AC091390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS78265.1; -.
DR   RefSeq; NP_001139682.2; NM_001146210.2.
DR   AlphaFoldDB; P0CI01; -.
DR   SMR; P0CI01; -.
DR   IntAct; P0CI01; 4.
DR   STRING; 9606.ENSP00000485230; -.
DR   iPTMnet; P0CI01; -.
DR   PhosphoSitePlus; P0CI01; -.
DR   BioMuta; SPDYE6; -.
DR   DMDM; 308191577; -.
DR   MassIVE; P0CI01; -.
DR   PeptideAtlas; P0CI01; -.
DR   PRIDE; P0CI01; -.
DR   ProteomicsDB; 52479; -.
DR   DNASU; 729597; -.
DR   Ensembl; ENST00000563237.3; ENSP00000485230.1; ENSG00000260097.3.
DR   GeneID; 729597; -.
DR   KEGG; hsa:729597; -.
DR   MANE-Select; ENST00000563237.3; ENSP00000485230.1; NM_001146210.4; NP_001139682.2.
DR   CTD; 729597; -.
DR   GeneCards; SPDYE6; -.
DR   HGNC; HGNC:35465; SPDYE6.
DR   HPA; ENSG00000260097; Tissue enhanced (testis).
DR   neXtProt; NX_P0CI01; -.
DR   VEuPathDB; HostDB:ENSG00000260097; -.
DR   eggNOG; ENOG502SSQN; Eukaryota.
DR   GeneTree; ENSGT00940000154173; -.
DR   InParanoid; P0CI01; -.
DR   OMA; PEHHETF; -.
DR   OrthoDB; 1480540at2759; -.
DR   PhylomeDB; P0CI01; -.
DR   PathwayCommons; P0CI01; -.
DR   SignaLink; P0CI01; -.
DR   BioGRID-ORCS; 729597; 29 hits in 182 CRISPR screens.
DR   ChiTaRS; SPDYE6; human.
DR   GenomeRNAi; 729597; -.
DR   Pharos; P0CI01; Tdark.
DR   PRO; PR:P0CI01; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P0CI01; protein.
DR   Bgee; ENSG00000260097; Expressed in bone marrow cell and 99 other tissues.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 2.
DR   Pfam; PF11357; Spy1; 2.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Speedy protein E6"
FT                   /id="PRO_0000399478"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  48330 MW;  8836BD49E5062B0B CRC64;
     MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
     PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSSILPEHHK
     DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
     MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
     WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKRWFQ LGHSMNPRAR
     KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKHRFQ LYRSMNSRAR KNRSQIVLFQ
     KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS