ID   16D10_MELIC             Reviewed;          43 AA.
AC   Q6YKB1;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=CLAVATA3/ESR (CLE)-related protein 16D10;
DE   AltName: Full=Esophageal gland cell secretory protein 16;
DE   Flags: Precursor;
GN   Name=16D10; Synonyms=MSP16;
OS   Meloidogyne incognita (Southern root-knot nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae;
OC   Meloidogyne; Meloidogyne incognita group.
OX   NCBI_TaxID=6306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Esophagus, and Gland;
RX   PubMed=12744507; DOI=10.1094/mpmi.2003.16.5.376;
RA   Huang G., Gao B., Maier T., Allen R., Davis E.L., Baum T.J., Hussey R.S.;
RT   "A profile of putative parasitism genes expressed in the esophageal gland
RT   cells of the root-knot nematode Meloidogyne incognita.";
RL   Mol. Plant Microbe Interact. 16:376-381(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INTERACTION WITH HOST SCL TRANSCRIPTION FACTORS SCL6 AND
RP   SCL21.
RX   PubMed=16673933; DOI=10.1094/mpmi-19-0463;
RA   Huang G., Dong R., Allen R., Davis E.L., Baum T.J., Hussey R.S.;
RT   "A root-knot nematode secretory peptide functions as a ligand for a plant
RT   transcription factor.";
RL   Mol. Plant Microbe Interact. 19:463-470(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=16985000; DOI=10.1073/pnas.0604698103;
RA   Huang G., Allen R., Davis E.L., Baum T.J., Hussey R.S.;
RT   "Engineering broad root-knot resistance in transgenic plants by RNAi
RT   silencing of a conserved and essential root-knot nematode parasitism
RT   gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:14302-14306(2006).
RN   [4]
RP   REVIEW.
RX   PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA   Mitchum M.G., Wang X., Davis E.L.;
RT   "Diverse and conserved roles of CLE peptides.";
RL   Curr. Opin. Plant Biol. 11:75-81(2008).
CC   -!- FUNCTION: Plays a role in the differentiation or division of feeding
CC       cells (syncytia) induced in plant roots during infection. Promotes host
CC       root growth. {ECO:0000269|PubMed:16673933,
CC       ECO:0000269|PubMed:16985000}.
CC   -!- SUBUNIT: Interacts with the SAW domain of host scarecrow-like
CC       transcription factors such as Arabidopsis thaliana SCL6 and SCL21.
CC       {ECO:0000269|PubMed:16673933}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16673933}. Host
CC       cytoplasm {ECO:0000250}. Host extracellular space {ECO:0000250}.
CC       Note=Secreted into host root cells via the nematode stylet to transform
CC       the recipient cells into enlarged multinucleate feeding cells called
CC       giant-cells or syncytia.
CC   -!- TISSUE SPECIFICITY: Highly expressed exclusively within the subventral
CC       esophageal gland cell during syncytium formation in host plants (at
CC       protein level). {ECO:0000269|PubMed:12744507,
CC       ECO:0000269|PubMed:16673933}.
CC   -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC       {ECO:0000305}.
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DR   EMBL; AY134435; AAN08582.1; -; mRNA.
DR   EMBL; DQ087264; AAZ77751.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6YKB1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043655; C:host extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Differentiation; Host cytoplasm; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..43
FT                   /note="CLAVATA3/ESR (CLE)-related protein 16D10"
FT                   /id="PRO_0000401220"
FT   MOTIF           31..43
FT                   /note="CLE"
SQ   SEQUENCE   43 AA;  4625 MW;  CC5E0C37E220AF2E CRC64;
     MFTNSIKNLI IYLMPLMVTL MLLSVSFVDA GKKPSGPNPG GNN