ID   SPE11_CAEEL             Reviewed;         299 AA.
AC   P54217;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Spermatocyte protein spe-11;
DE   AltName: Full=Defective spermatogenesis protein 11;
GN   Name=spe-11; ORFNames=F48C1.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Bristol N2;
RX   PubMed=8565851; DOI=10.1242/dev.122.1.391;
RA   Browning H., Strome S.;
RT   "A sperm-supplied factor required for embryogenesis in C. elegans.";
RL   Development 122:391-404(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION.
RX   PubMed=20971008; DOI=10.1016/j.cub.2010.09.059;
RA   Johnston W.L., Krizus A., Dennis J.W.;
RT   "Eggshell chitin and chitin-interacting proteins prevent polyspermy in C.
RT   elegans.";
RL   Curr. Biol. 20:1932-1937(2010).
CC   -!- FUNCTION: Paternally sperm-supplied factor required for embryogenesis
CC       (PubMed:8565851, PubMed:20971008). Plays a role in preventing
CC       polyspermy possibly by promoting the formation of a continuous and
CC       cohesive eggshell chitin layer (PubMed:20971008).
CC       {ECO:0000269|PubMed:20971008, ECO:0000269|PubMed:8565851}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:8565851}. Note=Localized to the perinuclear region
CC       of sperm.
CC   -!- TISSUE SPECIFICITY: Expressed in mature sperm.
CC       {ECO:0000269|PubMed:8565851}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during spermatogenesis.
CC       {ECO:0000269|PubMed:8565851}.
CC   -!- DISRUPTION PHENOTYPE: Worms fail to complete meiosis, form a weak
CC       eggshell, fail to orient properly the first mitotic spindle and fail to
CC       undergo cytokinesis. {ECO:0000269|PubMed:8565851}.
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DR   EMBL; U36483; AAA97861.1; -; Genomic_DNA.
DR   EMBL; FO080268; CCD62474.1; -; Genomic_DNA.
DR   PIR; T29546; T29546.
DR   RefSeq; NP_491569.1; NM_059168.3.
DR   AlphaFoldDB; P54217; -.
DR   BioGRID; 37637; 1.
DR   STRING; 6239.F48C1.7; -.
DR   iPTMnet; P54217; -.
DR   EPD; P54217; -.
DR   PaxDb; P54217; -.
DR   PeptideAtlas; P54217; -.
DR   EnsemblMetazoa; F48C1.7.1; F48C1.7.1; WBGene00004965.
DR   GeneID; 172179; -.
DR   KEGG; cel:CELE_F48C1.7; -.
DR   UCSC; F48C1.7; c. elegans.
DR   CTD; 172179; -.
DR   WormBase; F48C1.7; CE10744; WBGene00004965; spe-11.
DR   eggNOG; ENOG502R95F; Eukaryota.
DR   HOGENOM; CLU_1099323_0_0_1; -.
DR   InParanoid; P54217; -.
DR   OMA; RYLRSKW; -.
DR   OrthoDB; 1567079at2759; -.
DR   PRO; PR:P54217; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004965; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030703; P:eggshell formation; IMP:WormBase.
DR   GO; GO:0060468; P:prevention of polyspermy; IMP:WormBase.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..299
FT                   /note="Spermatocyte protein spe-11"
FT                   /id="PRO_0000072116"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  35150 MW;  98FC496EAF3C617D CRC64;
     MSDEEIDIST ALNNKTTPKK KSLKRNSNSQ EGYESPEERE IVYPSVFGAI GTPMAKSDNA
     KEWDEWKEKE RKKDKAEWKR YLRSKWDMTQ GHLPLVSDSE FLKGRKEHKE YNSKARMDIL
     DGLDEVNEGF FNCGKGAAMN IRYNDKNVSK KGAKKFVATV ETAMKKAGNP TMEQMMTDDL
     DEDEARAEAE WERQREQRKL ASRAYDAAMD EREDDAKYVP WDEYCQEMEE LGKELKIGEK
     HYKKWLEKKM DENKVTHKFN AYQLDLKCLD EDAFSNKKSL KSVVRNVQKF YRKMREPKK