SPE2B_HUMAN
ID SPE2B_HUMAN Reviewed; 402 AA.
AC A6NHP3; D6RBN0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Speedy protein E2B;
GN Name=SPDYE2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NHP3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NHP3-2; Sequence=VSP_039852;
CC -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR EMBL; AC105052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59507.1; -. [A6NHP3-1]
DR RefSeq; NP_001159811.1; NM_001166339.1. [A6NHP3-1]
DR RefSeq; XP_005250150.1; XM_005250093.3. [A6NHP3-1]
DR AlphaFoldDB; A6NHP3; -.
DR BioGRID; 138451; 4.
DR IntAct; A6NHP3; 1.
DR STRING; 9606.ENSP00000424058; -.
DR iPTMnet; A6NHP3; -.
DR PhosphoSitePlus; A6NHP3; -.
DR BioMuta; SPDYE2B; -.
DR MassIVE; A6NHP3; -.
DR PaxDb; A6NHP3; -.
DR PeptideAtlas; A6NHP3; -.
DR PRIDE; A6NHP3; -.
DR Antibodypedia; 74842; 37 antibodies from 9 providers.
DR DNASU; 100310812; -.
DR Ensembl; ENST00000436228.6; ENSP00000440393.1; ENSG00000173678.15. [A6NHP3-1]
DR Ensembl; ENST00000455020.3; ENSP00000414338.2; ENSG00000173678.15. [A6NHP3-2]
DR Ensembl; ENST00000507450.6; ENSP00000424058.1; ENSG00000173678.15. [A6NHP3-1]
DR GeneID; 100310812; -.
DR KEGG; hsa:100310812; -.
DR MANE-Select; ENST00000507450.6; ENSP00000424058.1; NM_001166339.2; NP_001159811.1.
DR UCSC; uc011kle.3; human. [A6NHP3-1]
DR CTD; 100310812; -.
DR GeneCards; SPDYE2B; -.
DR HGNC; HGNC:48334; SPDYE2B.
DR HPA; ENSG00000173678; Tissue enhanced (skeletal muscle, testis).
DR neXtProt; NX_A6NHP3; -.
DR OpenTargets; ENSG00000205238; -.
DR VEuPathDB; HostDB:ENSG00000173678; -.
DR eggNOG; ENOG502SSQN; Eukaryota.
DR GeneTree; ENSGT00940000154173; -.
DR HOGENOM; CLU_070353_0_0_1; -.
DR InParanoid; A6NHP3; -.
DR OMA; KHHEAFK; -.
DR OrthoDB; 1480540at2759; -.
DR PhylomeDB; A6NHP3; -.
DR BioGRID-ORCS; 100310812; 38 hits in 617 CRISPR screens.
DR GenomeRNAi; 100310812; -.
DR Pharos; A6NHP3; Tdark.
DR PRO; PR:A6NHP3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A6NHP3; protein.
DR Bgee; ENSG00000173678; Expressed in bone marrow cell and 103 other tissues.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR InterPro; IPR020984; Speedy.
DR PANTHER; PTHR31156; PTHR31156; 2.
DR Pfam; PF11357; Spy1; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..402
FT /note="Speedy protein E2B"
FT /id="PRO_0000399479"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039852"
SQ SEQUENCE 402 AA; 48290 MW; 282148A87EC8A6BD CRC64;
MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSSILPEHHK
DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ
KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS
