SPE39_BOVIN
ID SPE39_BOVIN Reviewed; 481 AA.
AC A5D796;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Spermatogenesis-defective protein 39 homolog;
DE Short=SPE-39;
DE AltName: Full=VPS33B-interacting protein in apical-basolateral polarity regulator;
DE AltName: Full=VPS33B-interacting protein in polarity and apical restriction;
GN Name=VIPAS39; Synonyms=SPE39, VIPAR;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Proposed to be involved in endosomal maturation implicating
CC in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may
CC play a role in the apical RAB11A-dependent recycling pathway and in the
CC maintenance of the apical-basolateral polarity. May play a role in
CC lysosomal trafficking, probably via association with the core HOPS
CC complex in a discrete population of endosomes; the functions seems to
CC be independent of VPS33B. May play a role in vesicular trafficking
CC during spermatogenesis. May be involved in direct or indirect
CC transcriptional regulation of E-cadherin (By similarity).
CC {ECO:0000250|UniProtKB:Q23288, ECO:0000250|UniProtKB:Q9H9C1}.
CC -!- SUBUNIT: Interacts with VPS33B. Associates with the homotypic fusion
CC and vacuole protein sorting (HOPS) complex; impaired by VPS33B.
CC Interacts with RAB11A (By similarity). {ECO:0000250|UniProtKB:Q8BGQ1,
CC ECO:0000250|UniProtKB:Q9H9C1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle
CC {ECO:0000250}. Early endosome {ECO:0000250|UniProtKB:Q9H9C1}. Recycling
CC endosome {ECO:0000250|UniProtKB:Q9H9C1}. Late endosome
CC {ECO:0000250|UniProtKB:Q9H9C1}. Note=Colocalizes in clusters with
CC VPS33B at cytoplasmic organelles. {ECO:0000250|UniProtKB:Q9H9C1}.
CC -!- SIMILARITY: Belongs to the VIPAS39 family. {ECO:0000305}.
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DR EMBL; BC140476; AAI40477.1; -; mRNA.
DR RefSeq; NP_001091469.1; NM_001098000.1.
DR AlphaFoldDB; A5D796; -.
DR SMR; A5D796; -.
DR STRING; 9913.ENSBTAP00000027283; -.
DR PaxDb; A5D796; -.
DR PRIDE; A5D796; -.
DR Ensembl; ENSBTAT00000027283; ENSBTAP00000027283; ENSBTAG00000020475.
DR GeneID; 508872; -.
DR KEGG; bta:508872; -.
DR CTD; 63894; -.
DR VEuPathDB; HostDB:ENSBTAG00000020475; -.
DR VGNC; VGNC:36798; VIPAS39.
DR eggNOG; KOG4677; Eukaryota.
DR GeneTree; ENSGT00390000013955; -.
DR HOGENOM; CLU_029487_0_0_1; -.
DR InParanoid; A5D796; -.
DR OMA; QIQSTLY; -.
DR OrthoDB; 812306at2759; -.
DR TreeFam; TF319640; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000020475; Expressed in trachea and 108 other tissues.
DR ExpressionAtlas; A5D796; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR GO; GO:0099023; C:vesicle tethering complex; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
DR GO; GO:0017185; P:peptidyl-lysine hydroxylation; IEA:Ensembl.
DR GO; GO:0043687; P:post-translational protein modification; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IBA:GO_Central.
DR Gene3D; 1.10.150.780; -; 1.
DR InterPro; IPR040057; Spe-39.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR PANTHER; PTHR13364; PTHR13364; 1.
DR Pfam; PF04840; Vps16_C; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoplasmic vesicle; Differentiation; Endosome; Phosphoprotein;
KW Protein transport; Reference proteome; Spermatogenesis; Transcription;
KW Transcription regulation; Transport.
FT CHAIN 1..481
FT /note="Spermatogenesis-defective protein 39 homolog"
FT /id="PRO_0000395738"
FT REGION 122..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9C1"
FT MOD_RES 116
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8BGQ1"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9C1"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9C1"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9C1"
FT MOD_RES 131
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9C1"
SQ SEQUENCE 481 AA; 55615 MW; D523D3499A26D6A1 CRC64;
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDFVDDDD EDDLERVSWT
GEPVGSISWS IKETAGNSGS SHEREQLKNR NSFSTYAQLP KPASTYSLSS FFRGRTRPGS
FQSLSDALSD TPAKSYAPEL GRPKGEYRDY SNDWSPSDTV RRLRKGKDKI QLLEEAVSMH
DGNVITAVLI FLKRTLSKEI LFRELEVRQV ALRHLIHFLK EIGDQKLLLD LFRFLDRTEE
LALSHYREHL NIQDPEKRKE FLKTCIGLPF SAEDSAHIQD HYTLLERQII IEANDRHLEL
AGQTEVFRKH PRKASILNMP LVTTLFYSCF YHYTEAEGTF SSPVNLKKTF KIPDKQYVLT
ALAARAKLRA WHDVDALFTT KNWLGYTKKR APIGFHRVVE ILHKNSAPVQ VLQEYVNLVE
DVDTKLNLAT KFKCHDVVID TCRDLKDRQQ LLAYRSKVDK GSAEEEKIDA LLNSSQIRWK
N
