ID   SPE4A_MOUSE             Reviewed;         268 AA.
AC   Q5IBH6;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Speedy protein E4A {ECO:0000305};
DE   AltName: Full=Rapid inducer of G2/M progression in oocytes E4A {ECO:0000305};
DE            Short=RINGO E4A {ECO:0000305};
DE            Short=mSpy/Ringo E4A {ECO:0000305};
GN   Name=Spdye4a {ECO:0000312|MGI:MGI:1921923};
GN   Synonyms=Spdyb {ECO:0000312|MGI:MGI:1921923};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAW32478.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CDK1, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=BALB/cJ {ECO:0000312|EMBL:AAW32478.1};
RC   TISSUE=Testis {ECO:0000312|EMBL:AAW32478.1};
RX   PubMed=15611625; DOI=10.4161/cc.4.1.1347;
RA   Cheng A., Xiong W., Ferrell J.E. Jr., Solomon M.J.;
RT   "Identification and comparative analysis of multiple mammalian Speedy/Ringo
RT   proteins.";
RL   Cell Cycle 4:155-165(2005).
CC   -!- FUNCTION: Promotes progression through the cell cycle via binding and
CC       activation of CDK1. {ECO:0000269|PubMed:15611625}.
CC   -!- SUBUNIT: Interacts with CDK1. Does not interact with CDK2 in vivo.
CC       {ECO:0000269|PubMed:15611625}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5MJ70}.
CC   -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:15611625}.
CC   -!- SIMILARITY: Belongs to the Speedy/Ringo family. {ECO:0000305}.
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DR   EMBL; AY820308; AAW32478.1; -; mRNA.
DR   CCDS; CCDS39368.1; -.
DR   RefSeq; NP_083324.3; NM_029048.3.
DR   AlphaFoldDB; Q5IBH6; -.
DR   SMR; Q5IBH6; -.
DR   STRING; 10090.ENSMUSP00000082882; -.
DR   iPTMnet; Q5IBH6; -.
DR   PhosphoSitePlus; Q5IBH6; -.
DR   PaxDb; Q5IBH6; -.
DR   PRIDE; Q5IBH6; -.
DR   ProteomicsDB; 257308; -.
DR   DNASU; 74673; -.
DR   Ensembl; ENSMUST00000085733; ENSMUSP00000082882; ENSMUSG00000039296.
DR   GeneID; 74673; -.
DR   KEGG; mmu:74673; -.
DR   UCSC; uc009ajs.1; mouse.
DR   CTD; 74673; -.
DR   MGI; MGI:1921923; Spdye4a.
DR   VEuPathDB; HostDB:ENSMUSG00000039296; -.
DR   eggNOG; ENOG502SSQN; Eukaryota.
DR   GeneTree; ENSGT00940000154173; -.
DR   InParanoid; Q5IBH6; -.
DR   OrthoDB; 1480540at2759; -.
DR   PhylomeDB; Q5IBH6; -.
DR   TreeFam; TF329827; -.
DR   BioGRID-ORCS; 74673; 4 hits in 44 CRISPR screens.
DR   PRO; PR:Q5IBH6; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q5IBH6; protein.
DR   Bgee; ENSMUSG00000039296; Expressed in spermatocyte and 2 other tissues.
DR   ExpressionAtlas; Q5IBH6; baseline and differential.
DR   Genevisible; Q5IBH6; MM.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB.
DR   InterPro; IPR020984; Speedy.
DR   PANTHER; PTHR31156; PTHR31156; 1.
DR   Pfam; PF11357; Spy1; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Nucleus; Reference proteome.
FT   CHAIN           1..268
FT                   /note="Speedy protein E4A"
FT                   /id="PRO_0000234115"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..265
FT                   /note="Speedy/Ringo box; Required for CDK-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q5IBH7"
SQ   SEQUENCE   268 AA;  30977 MW;  47ECD87EFCA8A2A4 CRC64;
     MGEGTPGVDS ARVQEEGGRD QSLGFVEGRI QVGRIVTAGQ LSLCSEEQSP QPGITRPSPG
     VVVDGESSGL AEPRVEATPQ PPSSIQKRKR DESLDSEDDL AELFEPDPQP VWSVEMLCGL
     RMRLKRRRVS TVRPEHHKVF TKLLEDPVVK KFLTWDKMLR VSDKYLLSMV IAYFSRAGLF
     SWQYRPIHFF LALYLANDME EDNQAPKQDI FYFLYGKSYA QRPMFHKLRF QFIRSMGWKI
     WVSREECEEI QAYNPDLWVW ARDRTNLT