ID   SPEA_BPT12              Reviewed;         251 AA.
AC   P0DJY8; P08095; P62560;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   29-SEP-2021, entry version 26.
DE   RecName: Full=Exotoxin type A;
DE   AltName: Full=Erythrogenic toxin;
DE   AltName: Full=SPE A;
DE   AltName: Full=Scarlet fever toxin;
DE   Flags: Precursor;
GN   Name=speA;
OS   Streptococcus pyogenes phage T12 (Bacteriophage T12).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae.
OX   NCBI_TaxID=35344;
OH   NCBI_TaxID=1314; Streptococcus pyogenes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3514452; DOI=10.1128/iai.52.1.144-150.1986;
RA   Weeks C.R., Ferretti J.J.;
RT   "Nucleotide sequence of the type A streptococcal exotoxin (erythrogenic
RT   toxin) gene from Streptococcus pyogenes bacteriophage T12.";
RL   Infect. Immun. 52:144-150(1986).
CC   -!- MISCELLANEOUS: Binds to major histocompatibility complex class II beta
CC       chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; U40453; AAC48868.1; -; Genomic_DNA.
DR   RefSeq; YP_009191734.1; NC_028700.1.
DR   SMR; P0DJY8; -.
DR   GeneID; 26519948; -.
DR   KEGG; vg:26519948; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0098676; P:modulation of host virulence by virus; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00277; STAPH_STREP_TOXIN_1; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Modulation of host virulence by virus; Signal; Toxin;
KW   Viral exotoxin; Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..251
FT                   /note="Exotoxin type A"
FT                   /id="PRO_0000426106"
FT   DISULFID        117..128
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  29246 MW;  54001FE4CCCBFCC3 CRC64;
     MENNKKVLKK MVFFVLVTFL GLTISQEVFA QQDPDPSQLH RSSLVKNLQN IYFLYEGDPV
     THENVKSVDQ LLSHDLIYNV SGPNYDKLKT ELKNQEMATL FKDKNVDIYG VEYYHLCYLC
     ENAERSACIY GGVTNHEGNH LEIPKKIVVK VSIDGIQSLS FDIETNKKMV TAQELDYKVR
     KYLTDNKQLY TNGPSKYETG YIKFIPKNKE SFWFDFFPEP EFTQSKYLMI YKDNETLDSN
     TSQIEVYLTT K