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SPEC_STRP1
ID   SPEC_STRP1              Reviewed;         235 AA.
AC   P0C0I5; P13380;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Exotoxin type C;
DE   AltName: Full=SPE C;
DE   Flags: Precursor;
GN   Name=speC; OrderedLocusNames=SPy_0711;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
CC   -!- FUNCTION: Causative agent of the symptoms associated with scarlet
CC       fever, have been associated with streptococcal toxic shock-like disease
CC       and may play a role in the early events of rheumatic fever.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binds to major histocompatibility complex class II beta
CC       chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AE004092; AAK33664.1; -; Genomic_DNA.
DR   RefSeq; NP_268943.1; NC_002737.2.
DR   AlphaFoldDB; P0C0I5; -.
DR   SMR; P0C0I5; -.
DR   STRING; 1314.HKU360_01603; -.
DR   PaxDb; P0C0I5; -.
DR   EnsemblBacteria; AAK33664; AAK33664; SPy_0711.
DR   KEGG; spy:SPy_0711; -.
DR   PATRIC; fig|160490.10.peg.605; -.
DR   HOGENOM; CLU_093855_1_0_9; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00277; STAPH_STREP_TOXIN_1; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Toxin; Virulence.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..235
FT                   /note="Exotoxin type C"
FT                   /id="PRO_0000041942"
SQ   SEQUENCE   235 AA;  27371 MW;  070534ABB952C1E0 CRC64;
     MKKINIIKIV FIITVILIST ISPIIKSDSK KDISNVKSDL LYAYTITPYD YKNCRVNFST
     THTLNIDTQK YRGKDYYISS EMSYEASQKF KRDDHVDVFG LFYILNSHTG EYIYGGITPA
     QNNKVNHKLL GNLFISGESQ QNLNNKIILE KDIVTFQEID FKIRKYLMDN YKIYDATSPY
     VSGRIEIGTK DGKHEQIDLF DSPNEGTRSD IFAKYKDNRI INMKNFSHFD IYLEK
 
 
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