ID   SPEC_STRP6              Reviewed;         235 AA.
AC   Q5XB82;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Exotoxin type C;
DE   AltName: Full=SPE C;
DE   Flags: Precursor;
GN   Name=speC; OrderedLocusNames=M6_Spy1196;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: Causative agent of the symptoms associated with scarlet
CC       fever, have been associated with streptococcal toxic shock-like disease
CC       and may play a role in the early events of rheumatic fever.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Superantigen that binds to major histocompatibility
CC       complex class II beta chain in a zinc-dependent manner, it may activate
CC       up to 20% of all T-cells. Superantigens bind simultaneously TCRs and
CC       MHC class II molecules resulting in a massive release of pyrogenic and
CC       inflammatory cytokines (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; CP000003; AAT87331.1; -; Genomic_DNA.
DR   RefSeq; WP_002985327.1; NC_006086.1.
DR   AlphaFoldDB; Q5XB82; -.
DR   SMR; Q5XB82; -.
DR   Allergome; 8279; Str py SPEC.
DR   EnsemblBacteria; AAT87331; AAT87331; M6_Spy1196.
DR   KEGG; spa:M6_Spy1196; -.
DR   HOGENOM; CLU_093855_1_0_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00277; STAPH_STREP_TOXIN_1; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Signal; Toxin; Virulence.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..235
FT                   /note="Exotoxin type C"
FT                   /id="PRO_0000035599"
SQ   SEQUENCE   235 AA;  27372 MW;  53EBD041B958C65B CRC64;
     MKKINIIKIV FIITVILIST ISPIIKSDSK KDISNVKSDL LYAYTITPYD YKDCRVNFST
     THTLNIDTQK YRGKDYYISS EMSYEASQKF KRDDHVDVFG LFYILNSHTG EYIYGGITPA
     QNNKVNHKLL GNLFISGESQ QNLNNKIILE KDIVTFQEID FKIRKYLMDN YKIYDATSPY
     VSGRIEIGTK DGKHEQIDLF DSPNEGTRSD IFAKYKDNRI INMKNFSHFD IYLEK