ID   SPEGN_HUMAN             Reviewed;         238 AA.
AC   A0A087WV53;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=SPEG neighbor protein {ECO:0000305};
GN   Name=SPEGNB {ECO:0000312|HGNC:HGNC:51251};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
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DR   EMBL; AC053503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001273740.1; NM_001286811.1.
DR   RefSeq; XP_011508771.1; XM_011510469.2.
DR   AlphaFoldDB; A0A087WV53; -.
DR   SMR; A0A087WV53; -.
DR   DNASU; 100996693; -.
DR   Ensembl; ENST00000651166.2; ENSP00000498687.1; ENSG00000286095.3.
DR   GeneID; 100996693; -.
DR   KEGG; hsa:100996693; -.
DR   MANE-Select; ENST00000651166.2; ENSP00000498687.1; NM_001286811.2; NP_001273740.1.
DR   UCSC; uc032oth.1; human.
DR   CTD; 100996693; -.
DR   DisGeNET; 100996693; -.
DR   GeneCards; SPEGNB; -.
DR   HGNC; HGNC:51251; SPEGNB.
DR   HPA; ENSG00000286095; Tissue enhanced (skeletal muscle, tongue).
DR   neXtProt; NX_A0A087WV53; -.
DR   VEuPathDB; HostDB:ENSG00000286095; -.
DR   GeneTree; ENSGT00940000163812; -.
DR   HOGENOM; CLU_069966_0_0_1; -.
DR   OMA; PFGECSD; -.
DR   OrthoDB; 1113501at2759; -.
DR   BioGRID-ORCS; 100996693; 2 hits in 92 CRISPR screens.
DR   GenomeRNAi; 100996693; -.
DR   PRO; PR:A0A087WV53; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000286095; Expressed in hindlimb stylopod muscle and 86 other tissues.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00015; IQ; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Immunoglobulin domain; Reference proteome; Repeat.
FT   CHAIN           1..238
FT                   /note="SPEG neighbor protein"
FT                   /id="PRO_0000448232"
FT   DOMAIN          29..55
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          54..143
FT                   /note="Ig-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DOMAIN          147..236
FT                   /note="Ig-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   238 AA;  26075 MW;  FDD07B8AF26D75BE CRC64;
     MSKAAPAKKP VAVAPAPGCT LDINDPQVQS AAIRIQASYR GHRSRKELRE KGPPRVLEPL
     KDVVLIEGSA AKLTCRISAF PDPFIRWSKD GKELRDGPKY RYVFEDPDVV ALVVRDGELA
     DLGQYSINVT NPFGQCSDSA RILVEVPTKI QKGPDNTKAR KGTTVTLTAE ILGEPAPDVG
     WTKDGEDIEE DDRVFFEIGS TTTTLTIRRA TPQDSGKYEV YVENSLGMDQ SFARVDVA