ID   SPEG_STRP1              Reviewed;         234 AA.
AC   Q9X5C7; Q491B7;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Exotoxin type G;
DE   AltName: Full=Pyrogenic exotoxin G;
DE   AltName: Full=SPE G;
DE   Flags: Precursor;
GN   Name=speG; OrderedLocusNames=SPy_0212, M5005_Spy0182;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M1;
RX   PubMed=9874566; DOI=10.1084/jem.189.1.89;
RA   Proft T., Moffatt S.L., Berkahn C.J., Fraser J.D.;
RT   "Identification and characterization of novel superantigens from
RT   Streptococcus pyogenes.";
RL   J. Exp. Med. 189:89-102(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Mitogenic for human peripheral blood lymphocytes.
CC   -!- MISCELLANEOUS: Binds to major histocompatibility complex class II beta
CC       chain.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AF124499; AAD30988.1; -; Genomic_DNA.
DR   EMBL; AE004092; AAK33303.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50801.1; -; Genomic_DNA.
DR   RefSeq; NP_268582.1; NC_002737.2.
DR   AlphaFoldDB; Q9X5C7; -.
DR   SMR; Q9X5C7; -.
DR   STRING; 1314.HKU360_00227; -.
DR   PaxDb; Q9X5C7; -.
DR   EnsemblBacteria; AAK33303; AAK33303; SPy_0212.
DR   KEGG; spy:SPy_0212; -.
DR   KEGG; spz:M5005_Spy0182; -.
DR   PATRIC; fig|160490.10.peg.186; -.
DR   HOGENOM; CLU_093855_1_0_9; -.
DR   OMA; NIHINTG; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Toxin; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..234
FT                   /note="Exotoxin type G"
FT                   /id="PRO_0000035601"
SQ   SEQUENCE   234 AA;  27262 MW;  49525C49E4BA2052 CRC64;
     MKTNILTIII LSCVFSYGSQ LAYADENLKD LKRSLRFAYN ITPCDYENVE IAFVTTNSIH
     INTKQKRSEC ILYVDSIVSL GITDQFIKGD KVDVFGLPYN FSPPYVDNIY GGIVKHSNQG
     NKSLQFVGIL NQDGKETYLP SEAVRIKKKQ FTLQEFDFKI RKFLMEKYNI YDSESRYTSG
     SLFLATKDSK HYEVDLFNKD DKLLSRDSFF KRYKDNKIFN SEEISHFDIY LKTH