ID   SPEG_STRP3              Reviewed;         234 AA.
AC   P0DG08; Q79YK9; Q8K8Q7;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Exotoxin type G;
DE   AltName: Full=Pyrogenic exotoxin G;
DE   AltName: Full=SPE G;
DE   Flags: Precursor;
GN   Name=speG; OrderedLocusNames=SpyM3_0155;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- FUNCTION: Mitogenic for human peripheral blood lymphocytes.
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binds to major histocompatibility complex class II beta
CC       chain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AE014074; AAM78762.1; -; Genomic_DNA.
DR   RefSeq; WP_011054152.1; NC_004070.1.
DR   AlphaFoldDB; P0DG08; -.
DR   SMR; P0DG08; -.
DR   EnsemblBacteria; AAM78762; AAM78762; SpyM3_0155.
DR   KEGG; spg:SpyM3_0155; -.
DR   HOGENOM; CLU_093855_1_0_9; -.
DR   OMA; NIHINTG; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   InterPro; IPR006177; Toxin_bac.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR00279; BACTRLTOXIN.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Signal; Toxin; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..234
FT                   /note="Exotoxin type G"
FT                   /id="PRO_0000035602"
SQ   SEQUENCE   234 AA;  27282 MW;  AD112C5F8B06F33D CRC64;
     MKTNILTIII LSCVFSYGSQ LAYADENLKD LKRSLRFAYN ITPCDYENVE IAFVTTNSIH
     INTKQKRSEC ILYVDSIVSL GITDQFIKGD KVDVFGLPYN FSPPYVDNIY GGIVKHSNQG
     NKSLQFVGIL NQDGKETYLP SEVVRIKKKQ FTLQEFDLKI RKFLMEKYNI YDSESRYTSG
     SLFLATKDSK HYEVDLFNKD DKLLSRDSFF KRYKDNKIFN SEEISHFDIY LKTY