ID   SPEH_STRPY              Reviewed;         236 AA.
AC   P0C0I6; Q9X5C8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Exotoxin type H;
DE   AltName: Full=SPE H;
DE   Flags: Precursor;
GN   Name=speH;
OS   Streptococcus pyogenes.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M15;
RX   PubMed=9874566; DOI=10.1084/jem.189.1.89;
RA   Proft T., Moffatt S.L., Berkahn C.J., Fraser J.D.;
RT   "Identification and characterization of novel superantigens from
RT   Streptococcus pyogenes.";
RL   J. Exp. Med. 189:89-102(1999).
CC   -!- FUNCTION: Mitogenic for human peripheral blood lymphocytes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Binds to major histocompatibility complex class II beta
CC       chain.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AF124500; AAD30989.1; -; Genomic_DNA.
DR   RefSeq; WP_010922229.1; NZ_WVGJ01000001.1.
DR   PDB; 1ET9; X-ray; 1.90 A; A=33-236.
DR   PDB; 1EU4; X-ray; 2.50 A; A=33-236.
DR   PDBsum; 1ET9; -.
DR   PDBsum; 1EU4; -.
DR   AlphaFoldDB; P0C0I6; -.
DR   SMR; P0C0I6; -.
DR   PATRIC; fig|1314.197.peg.958; -.
DR   OMA; AQEACEC; -.
DR   EvolutionaryTrace; P0C0I6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR006173; Staph_tox_OB.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   Pfam; PF01123; Stap_Strp_toxin; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Secreted; Signal; Toxin; Virulence.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..236
FT                   /note="Exotoxin type H"
FT                   /id="PRO_0000035603"
FT   HELIX           37..48
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   HELIX           50..52
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          53..59
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          70..74
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          79..83
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   HELIX           88..93
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          98..106
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          116..119
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          122..124
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          132..140
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          148..152
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          154..158
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   HELIX           159..173
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          179..181
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          187..193
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   TURN            194..196
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          197..202
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   HELIX           211..215
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   HELIX           216..218
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          223..225
FT                   /evidence="ECO:0007829|PDB:1ET9"
FT   STRAND          228..235
FT                   /evidence="ECO:0007829|PDB:1ET9"
SQ   SEQUENCE   236 AA;  27485 MW;  16352923907AD40D CRC64;
     MRYNCRYSHI DKKIYSMIIC LSFLLYSNVV QANSYNTTNR HNLESLYKHD SNLIEADSIK
     NSPDIVTSHM LKYSVKDKNL SVFFEKDWIS QEFKDKEVDI YALSAQEVCE CPGKRYEAFG
     GITLTNSEKK EIKVPVNVWD KSKQQPPMFI TVNKPKVTAQ EVDIKVRKLL IKKYDIYNNR
     EQKYSKGTVT LDLNSGKDIV FDLYYFGNGD FNSMLKIYSN NERIDSTQFH VDVSIS