ID   SPEM1_HUMAN             Reviewed;         309 AA.
AC   Q8N4L4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Spermatid maturation protein 1;
GN   Name=SPEM1; Synonyms=C17orf83;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for proper cytoplasm removal during spermatogenesis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Cytoplasm {ECO:0000250}.
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DR   EMBL; BC033882; AAH33882.1; -; mRNA.
DR   CCDS; CCDS42254.1; -.
DR   RefSeq; NP_955371.2; NM_199339.2.
DR   AlphaFoldDB; Q8N4L4; -.
DR   BioGRID; 131920; 4.
DR   IntAct; Q8N4L4; 2.
DR   STRING; 9606.ENSP00000315554; -.
DR   iPTMnet; Q8N4L4; -.
DR   PhosphoSitePlus; Q8N4L4; -.
DR   BioMuta; SPEM1; -.
DR   DMDM; 74728870; -.
DR   MassIVE; Q8N4L4; -.
DR   PaxDb; Q8N4L4; -.
DR   PeptideAtlas; Q8N4L4; -.
DR   PRIDE; Q8N4L4; -.
DR   ProteomicsDB; 71940; -.
DR   Antibodypedia; 2661; 114 antibodies from 17 providers.
DR   DNASU; 374768; -.
DR   Ensembl; ENST00000323675.4; ENSP00000315554.3; ENSG00000181323.8.
DR   Ensembl; ENST00000640564.2; ENSP00000492561.1; ENSG00000284598.2.
DR   GeneID; 374768; -.
DR   KEGG; hsa:374768; -.
DR   MANE-Select; ENST00000323675.4; ENSP00000315554.3; NM_199339.3; NP_955371.2.
DR   UCSC; uc002ggv.3; human.
DR   CTD; 374768; -.
DR   DisGeNET; 374768; -.
DR   GeneCards; SPEM1; -.
DR   HGNC; HGNC:32429; SPEM1.
DR   HPA; ENSG00000181323; Tissue enriched (testis).
DR   MIM; 615116; gene.
DR   neXtProt; NX_Q8N4L4; -.
DR   OpenTargets; ENSG00000181323; -.
DR   PharmGKB; PA162404476; -.
DR   VEuPathDB; HostDB:ENSG00000181323; -.
DR   eggNOG; ENOG502ST8J; Eukaryota.
DR   GeneTree; ENSGT00510000049389; -.
DR   HOGENOM; CLU_078808_0_0_1; -.
DR   InParanoid; Q8N4L4; -.
DR   OMA; PAICSYH; -.
DR   OrthoDB; 1151298at2759; -.
DR   PhylomeDB; Q8N4L4; -.
DR   TreeFam; TF338031; -.
DR   PathwayCommons; Q8N4L4; -.
DR   SignaLink; Q8N4L4; -.
DR   BioGRID-ORCS; 374768; 3 hits in 1064 CRISPR screens.
DR   GenomeRNAi; 374768; -.
DR   Pharos; Q8N4L4; Tdark.
DR   PRO; PR:Q8N4L4; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8N4L4; protein.
DR   Bgee; ENSG00000181323; Expressed in right testis and 25 other tissues.
DR   Genevisible; Q8N4L4; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR   GO; GO:0007291; P:sperm individualization; IBA:GO_Central.
DR   InterPro; IPR031368; SPEM1_N.
DR   Pfam; PF15670; Spem1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Developmental protein; Differentiation; Membrane;
KW   Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Spermatid maturation protein 1"
FT                   /id="PRO_0000307806"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          209..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          259..285
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  34773 MW;  55C2CAD33C8670E0 CRC64;
     MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW SRFRGVLYQV
     FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV MMTVSPPPAH RHRRRGSPTR
     CAHCPVAWAP DTDDEKPHQY PAICSYHWDV PEDWEGFQHT QGTWVPWSQD APESPPQTIR
     FQPTVEERPL KTGIWSELGL RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA
     PTLGPAVIPE FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN
     WVYRSLTGR