SPEM2_HUMAN
ID SPEM2_HUMAN Reviewed; 501 AA.
AC Q0P670;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized protein SPEM2;
GN Name=SPEM2 {ECO:0000312|HGNC:HGNC:27315}; Synonyms=C17orf74;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC113189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031286; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42255.1; -.
DR RefSeq; NP_783861.3; NM_175734.4.
DR AlphaFoldDB; Q0P670; -.
DR STRING; 9606.ENSP00000328061; -.
DR iPTMnet; Q0P670; -.
DR PhosphoSitePlus; Q0P670; -.
DR BioMuta; SPEM2; -.
DR DMDM; 261260060; -.
DR MassIVE; Q0P670; -.
DR PaxDb; Q0P670; -.
DR PeptideAtlas; Q0P670; -.
DR PRIDE; Q0P670; -.
DR ProteomicsDB; 58775; -.
DR Antibodypedia; 6127; 67 antibodies from 16 providers.
DR DNASU; 201243; -.
DR Ensembl; ENST00000333870.8; ENSP00000328061.3; ENSG00000184560.8.
DR Ensembl; ENST00000639609.2; ENSP00000492107.1; ENSG00000283714.2.
DR GeneID; 201243; -.
DR KEGG; hsa:201243; -.
DR MANE-Select; ENST00000333870.8; ENSP00000328061.3; NM_175734.5; NP_783861.3.
DR UCSC; uc002ggw.4; human.
DR CTD; 201243; -.
DR DisGeNET; 201243; -.
DR GeneCards; SPEM2; -.
DR HGNC; HGNC:27315; SPEM2.
DR HPA; ENSG00000184560; Tissue enriched (testis).
DR neXtProt; NX_Q0P670; -.
DR OpenTargets; ENSG00000184560; -.
DR PharmGKB; PA142672222; -.
DR VEuPathDB; HostDB:ENSG00000184560; -.
DR eggNOG; ENOG502RKNT; Eukaryota.
DR GeneTree; ENSGT00510000049558; -.
DR HOGENOM; CLU_045547_0_0_1; -.
DR InParanoid; Q0P670; -.
DR OMA; DVHIHCT; -.
DR OrthoDB; 646751at2759; -.
DR PhylomeDB; Q0P670; -.
DR TreeFam; TF337389; -.
DR PathwayCommons; Q0P670; -.
DR SignaLink; Q0P670; -.
DR BioGRID-ORCS; 201243; 7 hits in 1058 CRISPR screens.
DR GenomeRNAi; 201243; -.
DR Pharos; Q0P670; Tdark.
DR PRO; PR:Q0P670; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q0P670; protein.
DR Bgee; ENSG00000184560; Expressed in left testis and 17 other tissues.
DR ExpressionAtlas; Q0P670; baseline and differential.
DR Genevisible; Q0P670; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031368; SPEM1_N.
DR Pfam; PF15670; Spem1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..501
FT /note="Uncharacterized protein SPEM2"
FT /id="PRO_0000286623"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 316..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 108
FT /note="S -> A (in dbSNP:rs13290)"
FT /id="VAR_032145"
FT VARIANT 376
FT /note="Q -> R (in dbSNP:rs3892554)"
FT /id="VAR_032146"
FT CONFLICT 409
FT /note="Missing (in Ref. 2; BC031286)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 501 AA; 57131 MW; F14E33A15453E228 CRC64;
MENQLWHNTV RCCNQYQESP HDAEDILLLL LGLIVLVNIG INVATMMWHG LQNALDKMID
WATQKNEIQA SESPPSGPPD KAQDVHIHCI LDPVQVKMSR PTQYSSFSCH HFSNHHSSSL
LRCVRRRRRR HRRCRRRCCN HQQRPQNYRQ IPHSHSVFRN PHRSQKMSQL HRVPFFDQED
PDSYLEEEDN LPFPYPKYPR RGWGGFYQRA GLPSNVGLWG HQGGILASLP PPSLYLSPEL
RCMPKRVEAR SELRLQSYGR HGSQSRLWGN VEAEQWASSP PPPHRLPPNP SWVPVGHSPY
PSVGWMLYDS WDQRRRGTEG FERPPASVSR NARPEAQGCR EHHSPQSHQQ SLLGHAYGQS
HRSPHPSTEP LGYSSQDPRE VRRRAADWAE ALPAWRPLTT SASLTVLDEA SHQRTPAPSS
VLVPHSSQPW PKVQAADPAP PPTMFVPLSR NPGGNANYQV YDSLELKRQV QKSRARSSSL
PPASTSTLRP SLHRSQTEKL N
