ID   SPEM2_RAT               Reviewed;         504 AA.
AC   Q68FV4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uncharacterized protein SPEM2;
GN   Name=Spem2 {ECO:0000250|UniProtKB:Q0P670};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC079298; AAH79298.1; -; mRNA.
DR   RefSeq; NP_001017475.1; NM_001017475.1.
DR   AlphaFoldDB; Q68FV4; -.
DR   STRING; 10116.ENSRNOP00000059409; -.
DR   PaxDb; Q68FV4; -.
DR   Ensembl; ENSRNOT00000092506; ENSRNOP00000075824; ENSRNOG00000058939.
DR   GeneID; 497938; -.
DR   KEGG; rno:497938; -.
DR   UCSC; RGD:1565061; rat.
DR   CTD; 201243; -.
DR   RGD; 1565061; Spem2.
DR   eggNOG; ENOG502RKNT; Eukaryota.
DR   GeneTree; ENSGT00510000049558; -.
DR   HOGENOM; CLU_045547_0_0_1; -.
DR   InParanoid; Q68FV4; -.
DR   OMA; DVHIHCT; -.
DR   OrthoDB; 646751at2759; -.
DR   PhylomeDB; Q68FV4; -.
DR   TreeFam; TF337389; -.
DR   PRO; PR:Q68FV4; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000058939; Expressed in testis and 7 other tissues.
DR   ExpressionAtlas; Q68FV4; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031368; SPEM1_N.
DR   Pfam; PF15670; Spem1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..504
FT                   /note="Uncharacterized protein SPEM2"
FT                   /id="PRO_0000387571"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          103..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..377
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..392
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56915 MW;  A5863B1B4614E69B CRC64;
     MENQLWQSTL GCCSQYQESP QDAENILFLL LGLIILVNIS INVTTVIWHG LQNAIDKMFS
     RMHQKTAEVQ VTECPPKEPQ PANVQDVHIH CVLDPVQVKM AQPTQCSSSS THYFRKHSND
     RRSRRRYCYP RGSLQIRQSN QQQSCHSRQQ RLRNNRQFSH GYPPFRKQRQ SHKASQTRPM
     PFFDLEDRDS LLEDDQSCPH PKQPRRSRGG LYKPVRLASN AGLWGRQGGI LASLPLPSLY
     LSPEMRRLPK RVEAKSELRL QGFGPHYSQS RICGNVEAEQ WASSPPPPRR LLPNPSWVTV
     GYSPFPSGGH IPYDARDQWR RGTEGCEPPP AFVSRNLRSD AQGYRDHSSS QAHRQNFPSY
     THSQPNHSPP QSVGYSSRES HEVRRRAPDW SEAFPSRHPL TTSTSLTALG EASYQRAPTA
     SSGLVIPHSS QRLAEGQISD PTPPATTFVP LSRNPGGNAN YQVYDSLELK RQVQENRGRA
     SSLPPPSTSA SRPSLHRSRT GKLN