SPEM3_HUMAN
ID SPEM3_HUMAN Reviewed; 1196 AA.
AC A0A1B0GUW6;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2016, sequence version 1.
DT 03-AUG-2022, entry version 31.
DE RecName: Full=Uncharacterized protein SPEM3 {ECO:0000305};
GN Name=SPEM3 {ECO:0000312|HGNC:HGNC:53651};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AC113189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011507026.1; XM_011508724.2.
DR RefSeq; XP_011522098.1; XM_011523796.2.
DR AlphaFoldDB; A0A1B0GUW6; -.
DR SMR; A0A1B0GUW6; -.
DR BioMuta; ENSG00000283439; -.
DR jPOST; A0A1B0GUW6; -.
DR MassIVE; A0A1B0GUW6; -.
DR PeptideAtlas; A0A1B0GUW6; -.
DR Ensembl; ENST00000636696.4; ENSP00000490274.1; ENSG00000283439.4.
DR Ensembl; ENST00000640133.4; ENSP00000491037.1; ENSG00000284090.4.
DR MANE-Select; ENST00000636696.4; ENSP00000490274.1; NM_001364708.1; NP_001351637.1.
DR GeneCards; SPEM3; -.
DR HGNC; HGNC:53651; SPEM3.
DR HPA; ENSG00000283439; Tissue enriched (testis).
DR neXtProt; NX_A0A1B0GUW6; -.
DR VEuPathDB; HostDB:ENSG00000283439; -.
DR GeneTree; ENSGT00940000164517; -.
DR OMA; KKTPFTQ; -.
DR OrthoDB; 129456at2759; -.
DR Pharos; A0A1B0GUW6; Tdark.
DR PRO; PR:A0A1B0GUW6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A0A1B0GUW6; protein.
DR Bgee; ENSG00000283439; Expressed in left testis and 18 other tissues.
DR ExpressionAtlas; A0A1B0GUW6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031368; SPEM1_N.
DR Pfam; PF15670; Spem1; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1196
FT /note="Uncharacterized protein SPEM3"
FT /id="PRO_0000443446"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 150..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..402
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 128649 MW; 28F08BFB0F28AAF2 CRC64;
MGERAYHGAQ VCSGTNPRKC QDLGDSILLL LGSFILLNVW INVVTLLWKH LKSSLRILFR
HFFPKDKQPS GSHPICICSS VDPKNLCSKV SSRVHPRPGF LLRRVNHLDS WIPDTNDEKV
SACCCVPPKC GHAGVPRESA RGLYKAGMMG GGEAPQVTAS KAQASLLSRP ETSSQFPKMS
KLDTGPCHLP QESKTKTPDC APAEAPAQAQ VHSPTHTPVC TPTHPWTRST DHTAVHTPAH
SWTHSKARTP EGTHSQAQDT SAQAQAHTSA PTPAQTPAHI QAHTPAPTPA KASAHTKAHT
SAQAQTHSPP HTPEYTHSQA HSPEHTSAHS PAQAPMPVPA HPQAHAPEYT SAHAPAYIPD
HSHLVRSSVP VPTSAPAPPG TLAPATTPVL APTPAPVPAS APSPAPALVM ALTTTPVPDP
VPATTPAPII TPIPSTPPAF SHDLSTGHVV YDARREKQNF FHMSSPQNPE YSRKDLATLF
RPQEGQDLVS SGISEQTKQC SGDSAKLPAG SILGYLELRN MEWKNSDDAK DKFPQTKTSP
YCSFHPCSSE KNTDSQAPFY PKFLAYSRDT ACAKTCFHSA TTAQSSVCTL PPPFTLSLPL
VPPRSFVPPQ PTNHQRPSTL IQTPTVLPTS KSPQSILTSQ FPIPSLFATI SQPLIQPQCP
ECHESLGLTQ DSGLQRTPGP SKDSRVPRNL DLAQNPDLYK NPGLTQDPGL HENPGLAPNQ
GLHEFPGLPQ DSYLCQNPSP SQDFGLHKNS GITQDSHPQK NTGLTQEAGI LRSPCLTQSP
GLHKKTPFTQ TSDLQRSSGF TQDSGIYRNL EPNQETVIYK NQDLSQATDH QKNLGSSKDS
GGHKNTGNVQ DPGVCSTAGL TEDSGSQKGP YVPQDSEVNK SSGVIQESFL HKSPGLVQTS
GLPKCSGLTQ NSGDYKNPGL IQDCGGHKVK GLTQDSNLPS LTQATKVERR FSLPQDVGVY
RSSEHSQDSN LHKCPGINQD PGPHKDPALV QDSGLPKISG LTQESGPYKS SCLIPDPSLY
KNPSPALGSD FVQLLSLLQT PKSTLSLMKS SVPEKAAQKE DAQRHVLWAR VQLNENSCPS
KAQVVSNDLQ TFSEVPVLIE LQSSSWRAGS QHGAYRPVDT VPSGYQNYRQ MSMPTHINWK
SHCPGPGTQA GHVVFDARQR RLAVGKDKCE ALSPRRLHQE APSNSGKPSR SGDIRM
