SPEN_DROME
ID SPEN_DROME Reviewed; 5560 AA.
AC Q8SX83; Q9NHN1; Q9NJ17; Q9U6C3; Q9VPL1; Q9VPL2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Protein split ends;
GN Name=spen; ORFNames=CG18497;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION, ALTERNATIVE
RP PROMOTER USAGE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTANTS E9 AND
RP D57.
RC TISSUE=Embryo;
RX PubMed=10556062; DOI=10.1242/dev.126.23.5373;
RA Wiellette E.L., Harding K.W., Mace K.A., Ronshaugen M.R., Wang F.Y.,
RA McGinnis W.;
RT "spen encodes an RNP motif protein that interacts with Hox pathways to
RT repress the development of head-like sclerites in the Drosophila trunk.";
RL Development 126:5373-5385(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RC TISSUE=Embryo;
RX PubMed=10655223; DOI=10.1093/genetics/154.2.695;
RA Rebay I., Chen F., Hsiao F., Kolodziej P.A., Kuang B.H., Laverty T.,
RA Suh C., Voas M., Williams A., Rubin G.M.;
RT "A genetic screen for novel components of the Ras/mitogen-activated protein
RT kinase signaling pathway that interact with the yan gene of Drosophila
RT identifies split ends, a new RNA recognition motif-containing protein.";
RL Genetics 154:695-712(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10704397; DOI=10.1242/dev.127.7.1517;
RA Kuang B.H., Wu S.C.-Y., Shin Y.-A., Luo L., Kolodziej P.A.;
RT "split ends encodes large nuclear proteins that regulate neuronal cell fate
RT and axon extension in the Drosophila embryo.";
RL Development 127:1517-1529(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-2002.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [7]
RP FUNCTION.
RX PubMed=10790398; DOI=10.1093/genetics/155.1.233;
RA Lane M.E., Elend M., Heidmann D., Herr A., Marzodko S., Herzig A.,
RA Lehner C.F.;
RT "A screen for modifiers of cyclin E function in Drosophila melanogaster
RT identifies Cdk2 mutations, revealing the insignificance of putative
RT phosphorylation sites in Cdk2.";
RL Genetics 155:233-244(2000).
RN [8]
RP FUNCTION ON EGF RECEPTOR PATHWAY.
RX PubMed=10959845; DOI=10.1016/s0960-9822(00)00625-4;
RA Chen F., Rebay I.;
RT "split ends, a new component of the Drosophila EGF receptor pathway,
RT regulates development of midline glial cells.";
RL Curr. Biol. 10:943-946(2000).
RN [9]
RP FUNCTION ON WG PATHWAY.
RX PubMed=12783785; DOI=10.1242/dev.00527;
RA Lin H.V., Doroquez D.B., Cho S., Chen F., Rebay I., Cadigan K.M.;
RT "Splits ends is a tissue/promoter specific regulator of Wingless
RT signaling.";
RL Development 130:3125-3135(2003).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1174; SER-1596; SER-1600;
RP SER-1907; SER-1908; THR-2276; SER-2277; THR-2329; SER-2345; SER-2349;
RP SER-2351; SER-2403; SER-2404; SER-2407; THR-2410; SER-2476; THR-2478;
RP SER-2501; SER-2502; SER-2503; SER-2517; SER-2518; SER-2520; SER-2557;
RP SER-2558; SER-2584; SER-2586; SER-2588; SER-3011; SER-3018; THR-3125;
RP THR-3408; SER-3411; SER-3650; SER-3653; SER-3657; SER-3672; SER-3707 AND
RP SER-4938, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Probable corepressor protein, which regulates different key
CC pathways such as the EGF receptor and Wg pathways. Involved in neuronal
CC cell fate, survival and axon guidance, cell cycle regulation and
CC repression of head identity in the embryonic trunk. May act with the
CC Hox gene Deformed and the EGF receptor signaling pathway. Positive
CC regulator of the Wg pathway in larval tissues but not in embryonic
CC tissues. May act as a transcriptional corepressor protein, which
CC repress transcription via the recruitment of large complexes containing
CC histone deacetylase proteins. {ECO:0000269|PubMed:10556062,
CC ECO:0000269|PubMed:10790398, ECO:0000269|PubMed:10959845,
CC ECO:0000269|PubMed:12783785}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10704397}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8SX83-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8SX83-2; Sequence=VSP_008565, VSP_008566;
CC Name=3; Synonyms=SpenL;
CC IsoId=Q8SX83-3; Sequence=VSP_008567;
CC Name=4; Synonyms=SpenS;
CC IsoId=Q8SX83-4; Sequence=VSP_008565, VSP_008566, VSP_008567;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Expressed prior to cellularization in
CC stage 3 embryos, and in blastoderm cells, including pole cells.
CC Expressed throughout the rest of embryogenesis. Later, it is expressed
CC at higher level in epidermal cells and CNS.
CC {ECO:0000269|PubMed:10556062, ECO:0000269|PubMed:10704397}.
CC -!- DEVELOPMENTAL STAGE: Isoform 3 is expressed both maternally and
CC zygotically. {ECO:0000269|PubMed:10556062}.
CC -!- MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage.
CC -!- MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Produced by alternative splicing of isoform
CC 1. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: Produced by alternative splicing of isoform
CC 2. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RRM Spen family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF34661.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF188205; AAF13218.1; -; mRNA.
DR EMBL; AF184612; AAF26299.1; -; mRNA.
DR EMBL; AF221715; AAF34661.1; ALT_INIT; mRNA.
DR EMBL; AE014134; AAF51534.2; -; Genomic_DNA.
DR EMBL; AE014134; AAF51535.2; -; Genomic_DNA.
DR EMBL; AE014134; AAN10511.1; -; Genomic_DNA.
DR EMBL; AY094788; AAM11141.1; ALT_SEQ; mRNA.
DR RefSeq; NP_524718.2; NM_079979.5. [Q8SX83-3]
DR RefSeq; NP_722615.1; NM_164374.3. [Q8SX83-1]
DR RefSeq; NP_722616.1; NM_164375.3. [Q8SX83-4]
DR SMR; Q8SX83; -.
DR BioGRID; 68897; 28.
DR IntAct; Q8SX83; 7.
DR STRING; 7227.FBpp0077781; -.
DR iPTMnet; Q8SX83; -.
DR PaxDb; Q8SX83; -.
DR PRIDE; Q8SX83; -.
DR EnsemblMetazoa; FBtr0078121; FBpp0077780; FBgn0016977. [Q8SX83-3]
DR EnsemblMetazoa; FBtr0078122; FBpp0077781; FBgn0016977. [Q8SX83-1]
DR EnsemblMetazoa; FBtr0078123; FBpp0077782; FBgn0016977. [Q8SX83-4]
DR GeneID; 44205; -.
DR KEGG; dme:Dmel_CG18497; -.
DR CTD; 23013; -.
DR FlyBase; FBgn0016977; spen.
DR VEuPathDB; VectorBase:FBgn0016977; -.
DR eggNOG; KOG0112; Eukaryota.
DR GeneTree; ENSGT00940000157087; -.
DR HOGENOM; CLU_223086_0_0_1; -.
DR InParanoid; Q8SX83; -.
DR OMA; DYHHHAS; -.
DR PhylomeDB; Q8SX83; -.
DR Reactome; R-DME-9013422; RHOBTB1 GTPase cycle.
DR SignaLink; Q8SX83; -.
DR BioGRID-ORCS; 44205; 0 hits in 1 CRISPR screen.
DR ChiTaRS; spen; fly.
DR GenomeRNAi; 44205; -.
DR PRO; PR:Q8SX83; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0016977; Expressed in spermathecum and 30 other tissues.
DR ExpressionAtlas; Q8SX83; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0048749; P:compound eye development; IMP:FlyBase.
DR GO; GO:0050832; P:defense response to fungus; IMP:FlyBase.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0048106; P:establishment of thoracic bristle planar orientation; IMP:FlyBase.
DR GO; GO:0007403; P:glial cell fate determination; IMP:UniProtKB.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase.
DR GO; GO:0035321; P:maintenance of imaginal disc-derived wing hair orientation; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; IMP:UniProtKB.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0007379; P:segment specification; IMP:UniProtKB.
DR GO; GO:0035222; P:wing disc pattern formation; IMP:FlyBase.
DR CDD; cd12349; RRM2_SHARP; 1.
DR CDD; cd12350; RRM3_SHARP; 1.
DR CDD; cd12351; RRM4_SHARP; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034173; SHARP_RRM2.
DR InterPro; IPR034174; SHARP_RRM3.
DR InterPro; IPR034175; SHARP_RRM4.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR010912; SPOC_met.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF07744; SPOC; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF100939; SSF100939; 1.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
DR PROSITE; PS50917; SPOC; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Coiled coil;
KW Developmental protein; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Repressor; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..5560
FT /note="Protein split ends"
FT /id="PRO_0000081958"
FT DOMAIN 554..632
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 656..730
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 734..806
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 5393..5560
FT /note="SPOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00249"
FT REGION 42..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..2428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2450..2537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2549..2637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2664..2695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2736..2832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2844..3215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3257..3313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3341..3487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3572..3597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3673..3750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3787..3807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3821..4024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4036..4075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4098..4138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4248..4306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4426..4453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4471..4558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4723..4771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4920..4963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4984..5009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5176..5197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5220..5241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1449..1465
FT /evidence="ECO:0000255"
FT COILED 1902..2071
FT /evidence="ECO:0000255"
FT COILED 2732..2760
FT /evidence="ECO:0000255"
FT COILED 2925..2957
FT /evidence="ECO:0000255"
FT COILED 3026..3063
FT /evidence="ECO:0000255"
FT COILED 3905..3965
FT /evidence="ECO:0000255"
FT COILED 4465..4486
FT /evidence="ECO:0000255"
FT COMPBIAS 129..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1708..1735
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1839..1853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1854..1885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1886..1901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1902..2083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2098..2128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2196..2221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2251..2276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2277..2300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2303..2320
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2321..2339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2340..2365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2408..2422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2466..2489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2507..2522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2523..2537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2552..2567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2605..2637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2757..2771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2793..2828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2854..2920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2954..2970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2988..3002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3011..3026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3058..3082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3156..3215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3270..3284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3285..3313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3359..3383
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3391..3418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3435..3487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3676..3750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4098..4120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4471..4499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4500..4521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4522..4537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4736..4771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4938..4963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5179..5197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1174
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1596
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1600
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1907
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1908
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2276
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2277
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2329
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2345
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2349
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2351
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2403
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2404
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2407
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2410
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2476
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2478
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2501
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2502
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2503
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2517
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2518
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2520
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2557
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2558
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2584
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2586
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 2588
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3011
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3018
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3125
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3408
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3411
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3650
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3653
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3657
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3672
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 3707
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 4938
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:10556062,
FT ECO:0000303|PubMed:10655223"
FT /id="VSP_008565"
FT VAR_SEQ 58..59
FT /note="LK -> MR (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:10556062,
FT ECO:0000303|PubMed:10655223"
FT /id="VSP_008566"
FT VAR_SEQ 5167..5193
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:10556062,
FT ECO:0000303|PubMed:10655223"
FT /id="VSP_008567"
FT MUTAGEN 5471
FT /note="C->Y: In E9; induces head-like skeletal structures
FT in the trunk."
FT MUTAGEN 5507
FT /note="G->D: In D57; induces head-like skeletal structures
FT in the trunk."
FT CONFLICT 4074
FT /note="Q -> P (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 5560 AA; 600000 MW; 58F19621AF40D2A8 CRC64;
MFRCRNMVRD NSRNICFGKL AETTTTQQQQ QQQQFVVDSS TIINNNNNNN NNNNNQKLKR
STEEPPTNSF ERNYYDRTTS RLVTQYQANN STSLANSNSS PSSVSASASV FATAAGGSSE
RSRNRDRPYR NGSASVQGGG INSSNTTTTT AACTAGGSGS GAIGTGTGGL VGSGPGGVPQ
ALGDRSSTQN IHQNHQSARV APPQSWYEAA TAATTAQLKS SGGSGNAGAS AAVGFTMSSS
PINHHPHQHP HLQNPQHPHY TSSPVVGAGS CPSAAQGQPQ IQSQSQTTAV HRSVAYAGSA
ADDLLNTATS RNMLLHSSKL NKLLKGAGAT GSGGERSGSE SPGRAGGATP LTTTSTITNN
SFSSNSLNNT ITTATPTMPT IASGAAGSVG LGSGAEAGVC SNSGTASGDI LNVAAVLAAA
VDNGVPTHPI RTRHNLHGRS TTSSSRSHSR SPSSYSSSHS SSSSSHSSSH SHASSPVQSS
GNCAMAEGRS SRTVNSVTVT SNSSNPSGTA VTVSSAGVGG GCGSSSSSSS SSSSSGSSCL
TANPVVHSED NRPLAIRVRN LPARSSDTSL KDGLFHEYKK HGKVTWVKVV GQNSERYALV
CFKKPDDVEK ALEVSHDKHF FGCKIEVEPY QGYDVEDNEF RPYEAELDEY HPKSTRTLFI
GNLEKDITAG ELRSHFEAFG EIIEIDIKKQ GLNAYAFCQY SDIVSVVKAM RKMDGEHLGS
NRIKLGFGKS MPTNCVWIDG VDEKVSESFL QSQFTRFGAV TKVSIDRNRQ LALVLYDQVQ
NAQAAVKDMR GTILRRKKLQ VDFASRECQD AFYDKQEKQQ QQSSGSNPRF SRYESSASSL
QSRSRASSFS RHQNNSNDDC SPINTPGGAS SGISSASNLI NQSTSINISN IGTNACSAMP
APSLASAVVS CNVNASGTVP ASTSMPSGVS SSSSSLPMSP AALAQRHRMV RNARQTVDCD
FNEVGRLRFR SSEEVSGGAG NSTQFEDVRC DSPVTARQGS AVNCFTGPTA AVGESIDGTL
NNNQITGGAE GFTGSGGSIL SRRRCGKTPK DLHPVHNQRI QLAEQVEECP SSGDEGVVSP
RKRIKMDYHH HHHHSNASGV ESTGEHSSIN KPSPLLLSNC DVIHDPLNRK SEIRRVSETP
SGSPSIKFPG HLPSAPQSLM LSCRRPSIDV GALSALSSSS AFRHGIVGAS SMDQQHMMNA
SAAAKRRRVT TTMQQPSSSS TTNSSSGSGL GGISSLTPAD EYHHHVSRGR GHQLHSHHSH
EASGGESADG SRPGTPLCDE RPEVLPTEPR RLPPPRERVR ERTRDVMWLP LPKFGVLFFQ
QQQSRSSGGG GAGNSYLQQQ LGGGSTGGLG CIGAASSSAC SLNNSSLNAS QGMGSCSGST
FLPSPSSRYW RSSSHHQNQQ NNHQQQSQQL HGSSSSNTCL MASPARPRSL SSNSSDSDVP
GQNAGGSPSL DERLRNFEEN YERWSGGSSR EHISGHTPSS ATPSWQLSMH MNLSTGLNSH
QTSSASGNSN SSSGTVSSSA SNSRHKFLDI DELQPSDIVK SVLAKKSVFD DDFQRLNKNQ
WYDPSSSDFA LGSSSNIVTG SSLVANVSRH PGGPCSGNTS PALPNLAATK ATPIIGNCSG
GLGNSTGSKS AGLLQRLSSL SPMNSPQASM SPYNSPSPSP SVGGVTACLG QLTKPAAPGT
ASAGLSGGTA ASSSSPAANS GPTKGLQYPF PSHPPLPNTA APPPAVQPAP PPLPEMGKQS
RLTGQSSGNN LTKSLSVPDG PQSSPARVQL QKSASVPGST NVGAPSSLSL DSTTASVETS
ASISSSTSNG NSSLTSAAIH VQKPQQSTFV EEEHTKKSGT STSQSSSSSS KKISSTHDKL
HSKHNNRSES DKKIKKSDKN ASSSDKRKNS STSQSSKSAT PRIEDDSSEA DDTADKAEKN
QRHEKEKKER QEKREKDLRK QVEREEKDRK AQQEEREKED RKAKEEEKER EREKKAQEDR
EKKEREEREL REKEQRDKEQ KEKEIREKDL REKEQRERDN REKELRDKDL REKEMREKEQ
REKELHREKD QREREHREKE QSRRAMDVEQ EGRGGRMREL SSYQKSKMDI AGEASSLTAI
DCQHNKENAM DTIAQGTPGA SPSTPSDNTP KERSRKLSRN SPVRLHKRRL SSQESNHSAG
GGGSCGGSSH QIHHEDYVKR IRMENSQNIS VHSSNQRLND RRDSKEHKSS SFKEDKNSSS
HISRPHGCGG SSASSSKHHH RRDKHHQKGS ASSIETNSSI EVVVDPISQT KHNLNTSEEE
LQSHQPKREK EREHFSSHAN SSSSRHKSKR DHHHHREKKR HSVAESTNTD EEHTPQQHNP
HRRISAAGSG SAGELSSAAT NTSSGKLHHQ HHRRSVERKS SRGSDEGHHS SSKSLRAKLM
MLSSADSDDT DDASKKHSIF DIPDDCPNVS MYDKVKARSC KNMQRQAEEK KIKAKFSQLK
QSRAKKKRST SYDGDSDTEF EDRQHRNSGS SSFHGRYPGL SSSDDDDDEE THQRRISSDS
DAEHGGQDNQ GASTLADANR VRQMQQNLRR LCDGDDSSED EIRRNVMKHS HFGKRNSNST
RIASDSESQS QPAPDLTIKQ EHPIAPAQEI KREQLSDEEQ KFKSRHDSNS SIEERKLKTE
REIKTELGDF YNSSEYTYTG KLKEYSPETR KKHKKSKRRL KSSSTADTSA AQTPLVMTPL
TPSIFDVHSS SECKTKFDNF DDLKTECSSI PLEISAGERR KHKERKEKKR EKLRNMTEAT
VPNSPTTNDT SSEKLSKEER HRLKKSKKSK SMDNSCNTKI YNSSGAHPST SPSLPATPTS
APSTAQTSKR GEDKMEFIFG IISDEEESQF PEQAETNKDI IPSSVSTTGP IVSAALQTYK
QEPSTPNSKN EEAHIQLTVH EPEQQQQLER SRLSGGSSSS SHADRERHRR EKREKKRREK
SQREQQNQIH QKSSKVETKV DDDNSVDMDE AGRALEAQLM SDFDTKPISE EATPSTAATY
RSDMTDVFRF SDNEDNNSVD MTKQGVKSEQ QEQHKSKDKK KKKKRSKEEK QEKLLQQQRR
ESLPNVASTS SAPPTPGKLT VNVQAASKHA DLQLDAKHIS SPPVCKPSPS LPCLIGDDDD
DALHTPKAKP TTPSSRGNDG LTPSREKPRL ISPIPKTPTI ANSSTLSTQS AETPVSSGTV
ISSSALATTP TSSTAAGVSA APGLDNSPTS ASAQCKKKES FIPGFDGQLD DRISESAVQS
ISAEFNSTSL LDNIADEPKI PVASPPRATK PLDKLEESKS RVTISQEETE SAVSALLGES
FGTSSTTDYS LDGMDEMSSV NELETPTLVI AEPDEEAALA AKAIETAGEP ASILEEPEME
PEREAEPDPD PEAEIESEPV VEVLDPEELN KAVQSLKHED MMDIKADTPQ SERDLQIDTD
TEENPDEADS SGPSLKIDET VQSSSSPEKS ISNNSPTPRE TANIDIPNVE SQPKLSNEST
PQPSVITKLP FLDTPKTVPA GLPPSPVKIE PPTISKLQQP LVQPVQTVLP APHSTGSGIS
ANSVINLDLS NVISSCSNTS AASATASASA SISFGSPTAS QNAMPQASTP KQGPITPQQA
IRTQSLIMQP PTISIPEQTP HFAVPQMVLS PQSHHPQQPG TYMVGIRAPS PHSPLHSPGR
GVAQSRLVGQ LSPVGRPMVS QPSPQQQVQQ TQQQHALITS PQSSNISPLA SPTTRVLSSS
NSPTTSKVNS YQPRNQQVPQ QPSPKSVAEV QTTPQLMTIP LQKMTPIQVP HHPTIISKVV
TVQPQQATQS QVASSPPLGS LPPHKNVHLN AHQNQQQPQV IAKMTAHQHQ QHMQQFMHQQ
MIQRQQHMQQ QQLHGQSQQI TSAPQHQMHQ QHQAQQQQQH HNQQHLNQQL HAQQHPTQKQ
HQAQQQFNQQ IQQHQSQQQH QVQQQNQAQQ QHLSQQQHQS QQQLNQQHQA QQQQLQQIQK
LQQMHGPQQQ QKSPQGVGHL GGSTSIFASQ QHNSQLPARG VPQQQHPQQL SHSSPCKPNT
LVSVNQGVQP PAILTRVGSH SQPNQQQQLP HQQSSSGHPH QKQLSSPGAN LPLQTPLNVI
QNTPKIIVQQ HIVAQNQVPP PQTQGNAIHY PQNQGKDSTP PGHVEPTPAM SAQKTSESVS
VIRTPTPTTG LAVISANTVG SLLTEENLIK ISQPKQDELI EQDSKEVDSD YWSAKEVNID
SVIKKLDTPL ASKDAKRAVE MQAIAPAPIP NPQPGNQSMA QETALPTTSM SVNNSNDHDT
EDETETRQLP PAKPPIPTVG RPPGRGGSAK RGRQPRGAKK VGGFPLNSVT AAPPGVDSLV
VQPGDNGVQT RLRKPVTAPV TRGRKGRPPR NLLLQQQQLQ QQQLDIQRKG MEMVTSATSS
TPLPTPIPTS SVLTAAEKKA RNQALTQAQE QNQVASQVGT GQDIYEFHED GGEEPKPKTI
SSVAPSAEDQ RPRLILTINK TQPSIKNISE MEQTIQQQQQ QQSEVISNTD PIGGDNSESC
NTRKSRRLQE KEDRSTVDDI IEDVVRNTNT PTGTGPHLPK GAQTPPRRSG RNAQAKKTDA
VQIINAVGRP RRSKDRKTIG EQTANLIEEV TASNATVAAS HLAPPEGAGV ESHVPQLDAK
EVEPVSVVTP ISTPAPVSVA APVTVPVPAM VPVKPTMPQH PKKKAIAAAE IESYQAINSS
IPSGGLPMHQ TAAPATQKIT GGVADAVSKA LVDPVTGVIT AGMPQGKEGN LPAATAAAPA
NSSNEDGQAA PPPQLQHQQQ QQHPQQPPQQ QANLQINTTL IPSGLPNPIT ALGKSVQLET
SAAALLNKPV SVLVKGNASQ VIQQQQPQIV APAKQPIILQ QNPLPTVLHH AQHTTVRPPQ
PLKAHVLNRE KNIQQQLTPT KQAVAQPPQH APHSGHMLLT DTAGNQQLVQ PQIIARHLQQ
QQHLQVNVPP PTAHSPHSPR IPSQQQQLGP GASISPQQQQ PQTVVIKQAA SAAQPQILHV
VSSKASVVPQ PQQQQLPPTS STGPHLQLAK PNYSYAPTVL TPTLPAVQQQ QQQHLYKQNN
QQKGAQIQMP PHGIIMPTHP GMLLQQKLPA HLQPQQHQLN PSPPPGKPNP VLHGLQSGQI
MPGSVGSPPP VSAAVLKTAQ QQVNSVVPVA GIRTAIPNIS PQSQPRVSPL VLPPGISGVP
PFDASLHDLG AYVSGRRTQS PPPAHQQASP ITPNDSTYRG VTASRDFMLY QHHLMRGGDY
DDKMGSSPPL ELRRPGSGPP RTIAVPHSLQ SPQDRTAADS PQMAQVYVHN TRIPPAHFSE
IASRGLYDSG ALQLEPPPAH RPTATISVVV PQQMPAVSSG SPFIGRDGSV QPGSHHHPGK
AMDMQLDEMD RMSMIAAVVQ QQQEHLPPAL PAGMELASQQ APPAMAPPPG DSLVTLLQRY
PVMWQGLLAL KTDQAAVQMH FVHGNPNVAR ASLPSLVETN TPLLRIAQRM RLEQTQLEGV
AKKMQVDKEH CMLLALPCGR DHADVLQHSR NLQTGFITYL QQKMAAGIVN IPIPGSEQAA
YVVHIFPSCD FANENLERAA PDLKNRVAEL AHLLIVIATV
