SPER1_ARATH
ID SPER1_ARATH Reviewed; 178 AA.
AC Q84X40; Q84X41; Q9SL73;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein SPEAR1 {ECO:0000303|PubMed:25527103};
DE AltName: Full=SPL-like, EAR-containing protein 1 {ECO:0000303|PubMed:25527103};
DE AltName: Full=TCP interactor containing EAR motif protein 2 {ECO:0000303|PubMed:23444332};
GN Name=SPEAR1 {ECO:0000303|PubMed:25527103};
GN Synonyms=TIE2 {ECO:0000303|PubMed:23444332};
GN OrderedLocusNames=At2g20080 {ECO:0000312|Araport:AT2G20080};
GN ORFNames=T2G17.12 {ECO:0000312|EMBL:AAO37152.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAO37152.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=23444332; DOI=10.1105/tpc.113.109223;
RA Tao Q., Guo D., Wei B., Zhang F., Pang C., Jiang H., Zhang J., Wei T.,
RA Gu H., Qu L.J., Qin G.;
RT "The TIE1 transcriptional repressor links TCP transcription factors with
RT TOPLESS/TOPLESS-RELATED corepressors and modulates leaf development in
RT Arabidopsis.";
RL Plant Cell 25:421-437(2013).
RN [6]
RP GENE FAMILY, NOMENCLATURE, AND INTERACTION WITH SPL AND SPEAR2.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
CC -!- FUNCTION: Adapter-like transcriptional repressor recruiting TPL/TPR
CC corepressors to inhibit TCP transcription factors.
CC {ECO:0000250|UniProtKB:Q6IDB0}.
CC -!- SUBUNIT: Interacts with SPL and SPEAR2. {ECO:0000269|PubMed:25527103}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q84X40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q84X40-2; Sequence=VSP_058190;
CC Name=3;
CC IsoId=Q84X40-3; Sequence=VSP_058189, VSP_058191;
CC -!- TISSUE SPECIFICITY: Not detected in leaves.
CC {ECO:0000269|PubMed:23444332}.
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DR EMBL; AC006081; AAD24402.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06962.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06963.1; -; Genomic_DNA.
DR EMBL; AY219062; AAO37152.1; -; mRNA.
DR EMBL; AY649273; AAT69190.1; -; mRNA.
DR EMBL; AY219061; AAO37151.1; -; mRNA.
DR EMBL; AY219060; AAO37150.1; -; mRNA.
DR PIR; G84584; G84584.
DR RefSeq; NP_179598.2; NM_127566.4. [Q84X40-1]
DR RefSeq; NP_973486.1; NM_201757.2. [Q84X40-2]
DR AlphaFoldDB; Q84X40; -.
DR STRING; 3702.AT2G20080.1; -.
DR PaxDb; Q84X40; -.
DR PRIDE; Q84X40; -.
DR ProteomicsDB; 245344; -. [Q84X40-1]
DR EnsemblPlants; AT2G20080.1; AT2G20080.1; AT2G20080. [Q84X40-1]
DR EnsemblPlants; AT2G20080.2; AT2G20080.2; AT2G20080. [Q84X40-2]
DR GeneID; 816527; -.
DR Gramene; AT2G20080.1; AT2G20080.1; AT2G20080. [Q84X40-1]
DR Gramene; AT2G20080.2; AT2G20080.2; AT2G20080. [Q84X40-2]
DR KEGG; ath:AT2G20080; -.
DR Araport; AT2G20080; -.
DR TAIR; locus:2061629; AT2G20080.
DR eggNOG; ENOG502RXQS; Eukaryota.
DR HOGENOM; CLU_094368_0_0_1; -.
DR InParanoid; Q84X40; -.
DR OMA; PAHQTIM; -.
DR OrthoDB; 1441325at2759; -.
DR PhylomeDB; Q84X40; -.
DR PRO; PR:Q84X40; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q84X40; baseline and differential.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:TAIR.
DR InterPro; IPR040356; SPEAR.
DR PANTHER; PTHR33388; PTHR33388; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..178
FT /note="Protein SPEAR1"
FT /id="PRO_0000435866"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 46..54
FT /note="SPL"
FT /evidence="ECO:0000305"
FT MOTIF 170..176
FT /note="EAR"
FT /evidence="ECO:0000305"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 78..105
FT /note="EDVRMQGGYSSIPSQSSAPYGFYPNMMM -> VTYTNTSLHNRDSDPKASKL
FT IKTRYICV (in isoform 3)"
FT /id="VSP_058189"
FT VAR_SEQ 78..104
FT /note="Missing (in isoform 2)"
FT /id="VSP_058190"
FT VAR_SEQ 106..178
FT /note="Missing (in isoform 3)"
FT /id="VSP_058191"
SQ SEQUENCE 178 AA; 19563 MW; AEFBE5E8A5EE1412 CRC64;
MGSTFFGRPN VVGSSPPSSS PTSSSSSPAT RRGKKNGSEK PKQPQRGLGV AQLEKIRLHG
EMSCNSFNSY NPSLYPQEDV RMQGGYSSIP SQSSAPYGFY PNMMMGVHRD QYDRATMSWN
PSYGILESQH SLEPNITRHF LNEDPSSTTR RSKSLGSGIQ HSGSSENQEV DLELRLSL
