SPER2_ARATH
ID SPER2_ARATH Reviewed; 300 AA.
AC F4IGU3; O22954; Q84WX4;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Protein SPEAR2 {ECO:0000303|PubMed:25527103};
DE AltName: Full=SPL-like, EAR-containing protein 2 {ECO:0000303|PubMed:25527103};
DE AltName: Full=TCP interactor containing EAR motif protein 4 {ECO:0000303|PubMed:23444332};
GN Name=SPEAR2 {ECO:0000303|PubMed:25527103};
GN Synonyms=TIE4 {ECO:0000303|PubMed:23444332};
GN OrderedLocusNames=At2g34010 {ECO:0000312|Araport:AT2G34010};
GN ORFNames=T14G11.13 {ECO:0000312|EMBL:AAB67619.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=23444332; DOI=10.1105/tpc.113.109223;
RA Tao Q., Guo D., Wei B., Zhang F., Pang C., Jiang H., Zhang J., Wei T.,
RA Gu H., Qu L.J., Qin G.;
RT "The TIE1 transcriptional repressor links TCP transcription factors with
RT TOPLESS/TOPLESS-RELATED corepressors and modulates leaf development in
RT Arabidopsis.";
RL Plant Cell 25:421-437(2013).
RN [5]
RP GENE FAMILY, NOMENCLATURE, INTERACTION WITH SPL; SPEAR1; SPEAR3 AND SPEAR4,
RP AND SUBUNIT.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
CC -!- FUNCTION: Adapter-like transcriptional repressor recruiting TPL/TPR
CC corepressors to inhibit TCP transcription factors (By similarity). May
CC be involved in leaf development. {ECO:0000250|UniProtKB:Q6IDB0,
CC ECO:0000305|PubMed:23444332}.
CC -!- SUBUNIT: Homodimer and heterodimer with SPL and SPEARs
CC (PubMed:25527103). Interacts with SPL, SPEAR1, SPEAR3 and SPEAR4
CC (PubMed:25527103). {ECO:0000269|PubMed:25527103}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves. {ECO:0000269|PubMed:23444332}.
CC -!- MISCELLANEOUS: Knock down expression of SPEAR2/TIE4 and SPEAR4/TIE3 by
CC RNAi in a SPEAR3/TIE1 null mutant produces lines displaying epinastic
CC leaves. {ECO:0000269|PubMed:23444332}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB67619.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002341; AAB67619.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08906.1; -; Genomic_DNA.
DR EMBL; AY219137; AAO37224.1; -; mRNA.
DR PIR; C84751; C84751.
DR RefSeq; NP_180948.2; NM_128952.3.
DR AlphaFoldDB; F4IGU3; -.
DR SMR; F4IGU3; -.
DR STRING; 3702.AT2G34010.1; -.
DR PaxDb; F4IGU3; -.
DR PRIDE; F4IGU3; -.
DR EnsemblPlants; AT2G34010.1; AT2G34010.1; AT2G34010.
DR GeneID; 817962; -.
DR Gramene; AT2G34010.1; AT2G34010.1; AT2G34010.
DR KEGG; ath:AT2G34010; -.
DR Araport; AT2G34010; -.
DR TAIR; locus:2055450; AT2G34010.
DR HOGENOM; CLU_919369_0_0_1; -.
DR InParanoid; F4IGU3; -.
DR OMA; QWRSKKP; -.
DR OrthoDB; 1138412at2759; -.
DR PRO; PR:F4IGU3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IGU3; baseline and differential.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:TAIR.
DR InterPro; IPR040356; SPEAR.
DR PANTHER; PTHR33388; PTHR33388; 3.
PE 1: Evidence at protein level;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..300
FT /note="Protein SPEAR2"
FT /id="PRO_0000435867"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 37..45
FT /note="SPL"
FT /evidence="ECO:0000305"
FT MOTIF 294..300
FT /note="EAR"
FT /evidence="ECO:0000305"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 33576 MW; FCEB986D93C5C8D4 CRC64;
MCSNNNTSSG SYGELQLHDE SSGSCRKKQK KDKVRRRGPG VAELEKIRLQ EEYKPPLSSS
PSLPNIDHHH HTLFAPASSV YDLVMTSPNF SFPEKLASTL PVFPISYGSL IPPAPIFQRS
QHSLMMNLPN PSPGAGRFYQ FIEPPSNQRS CVDSVSQFLE EENKKIFTAK KRPWPFLTDT
TKPSVGPTTT STIIRPDATQ NRSMGITPVQ ETGTTTSNPI AIDSPTSIPR HYPRFIPLGL
QYEQQQQKLK DLDETMQWRS KKPFYSFIPS GDPSNDDQEQ RPCDLFGSAA DHGIDLNLKL
