ID   SPER_STRPU              Reviewed;         532 AA.
AC   P16264;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Egg peptide speract receptor;
DE   Flags: Precursor;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 477-489.
RX   PubMed=2538832; DOI=10.1073/pnas.86.7.2128;
RA   Dangott L.J., Jordan J.E., Bellet R.A., Garbers D.L.;
RT   "Cloning of the mRNA for the protein that crosslinks to the egg peptide
RT   speract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:2128-2132(1989).
CC   -!- FUNCTION: Receptor for the egg peptide speract.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; J04518; AAA30078.1; -; mRNA.
DR   PIR; A32751; A32751.
DR   RefSeq; NP_999772.1; NM_214607.1.
DR   AlphaFoldDB; P16264; -.
DR   SMR; P16264; -.
DR   PRIDE; P16264; -.
DR   EnsemblMetazoa; NM_214607; NP_999772; LOC373458.
DR   GeneID; 373458; -.
DR   KEGG; spu:373458; -.
DR   HOGENOM; CLU_002555_11_0_1; -.
DR   OMA; EERILDC; -.
DR   OrthoDB; 84635at2759; -.
DR   PhylomeDB; P16264; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 4.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 4.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 4.
DR   SUPFAM; SSF56487; SSF56487; 4.
DR   PROSITE; PS00420; SRCR_1; 4.
DR   PROSITE; PS50287; SRCR_2; 4.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..30
FT   CHAIN           31..532
FT                   /note="Egg peptide speract receptor"
FT                   /id="PRO_0000033231"
FT   TOPO_DOM        31..491
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        492..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        521..532
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          43..144
FT                   /note="SRCR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          153..257
FT                   /note="SRCR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          264..366
FT                   /note="SRCR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          382..485
FT                   /note="SRCR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        459
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        68..133
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        81..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        112..122
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        178..244
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        191..256
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        223..233
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        289..355
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        302..365
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        335..345
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        406..475
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        419..484
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DISULFID        454..465
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   532 AA;  57820 MW;  742533E09576BCB8 CRC64;
     MGLPMMLQQY CWAACLVICI AISSVDDVGA EQNYGREAVE GNIRLIHGRT ENEGSVEIYH
     ATRWGGVCDW WWHMENANVT CKQLGFPGAR QFYRRAYFGA HVTTFWVYKM NCLGNETRLE
     DCYHRPYGRP WLCNAQWAAG VECLPKDEPQ GSLRMILGDV PNEGTLETFW DGAWGSVCHT
     DFGTPDGNVA CRQMGYSRGV KSIKTDGHFG FSTGPIILDA VDCEGTEAHI TECNMPVTPY
     QHACPYTHNW DVGVVCKPNV EGDIRLMDGS GPHEGRVEIW HDDAWGTICD DGWDWADANV
     VCRQAGYRGA VKASGFKGED FGFTWAPIHT SFVMCTGVED RLIDCILRDG WTHSCYHVED
     ASVVCATDDD DTIEIEPKHT RVRIVGMGQG QGRVEVSLGN GWGRVCDPDW SDHEAKTVCY
     HAGYKWGASR AAGSAEVSAP FDLEAPFIID GITCSGVENE TLSQCQMKVS ADMTCATGDV
     GVVCEGSTAP PSGMSIAVIG GAAGGGVAGL AVAAFAFYYI KFVKPAGGGG QA