ID   SPESP_BOVIN             Reviewed;         366 AA.
AC   Q32KL7;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Sperm equatorial segment protein 1 {ECO:0000250|UniProtKB:Q6UW49};
DE   Flags: Precursor;
GN   Name=SPESP1 {ECO:0000250|UniProtKB:Q6UW49};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI10033.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI10033.1};
RC   TISSUE=Liver {ECO:0000312|EMBL:AAI10033.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in fertilization ability of sperm.
CC       {ECO:0000250|UniProtKB:Q9D5A0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q6UW49}. Note=Small proacrosomal granules
CC       (during the Golgi phase), enlarged acrosomal vesicles (during the cap
CC       phase), acrosome (during the elongating phase), equatorial segment of
CC       the acrosome (during the maturation phase) (By similarity). After
CC       acrosome reaction localizes to the equatorial segment region in both
CC       noncapacitated and capacitated, acrosome-reacted sperm (By similarity).
CC       {ECO:0000250|UniProtKB:Q6UW49, ECO:0000250|UniProtKB:Q9D5A0}.
CC   -!- PTM: Glycosylated. In testis there are two predominant forms of 77- and
CC       67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput,
CC       corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms
CC       contain complex carbohydrate residues. Epididymal sperm forms are N-
CC       glycosylated. Then undergoes significant glycosylation in the testis
CC       and that the majority of these glycoconjugates are removed by the time
CC       sperm reach the caput epididymis. {ECO:0000250|UniProtKB:Q9D5A0}.
CC   -!- SIMILARITY: Belongs to the SPESP1 family. {ECO:0000255}.
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DR   EMBL; BC110032; AAI10033.1; -; mRNA.
DR   RefSeq; NP_001073241.1; NM_001079773.1.
DR   AlphaFoldDB; Q32KL7; -.
DR   SMR; Q32KL7; -.
DR   STRING; 9913.ENSBTAP00000007865; -.
DR   PaxDb; Q32KL7; -.
DR   GeneID; 513571; -.
DR   KEGG; bta:513571; -.
DR   CTD; 246777; -.
DR   eggNOG; ENOG502SG7W; Eukaryota.
DR   HOGENOM; CLU_787463_0_0_1; -.
DR   InParanoid; Q32KL7; -.
DR   OrthoDB; 1348911at2759; -.
DR   TreeFam; TF337441; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR   GO; GO:0007340; P:acrosome reaction; IBA:GO_Central.
DR   GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IBA:GO_Central.
DR   GO; GO:0035036; P:sperm-egg recognition; ISS:UniProtKB.
DR   InterPro; IPR026743; Equatorial_segment.
DR   PANTHER; PTHR31667; PTHR31667; 1.
DR   Pfam; PF15754; SPESP1; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Glycoprotein;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..366
FT                   /note="Sperm equatorial segment protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000274544"
FT   REGION          139..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   366 AA;  41410 MW;  3AC08E20D4F6F110 CRC64;
     MKFLVLLVAL LLWPSSLPAY RRVTVTPDEE QNLNHYVQVL QNLILSVPTK EPGRQKKSKS
     PNNANFIGPR VSRVKELKYT HDVGPGDNDV LINPVSEETT TFPTRGFTLE IDKKKRTKST
     AFWSIKPSNV SVVLHAKEPF IEKDEPEPEP EPEPEPEPVE HRTGAPTQVP SVTEPSQDVT
     SLSGSTDLGT ATEEEDVPQL SGDNEMDYLE SHDMYNEDVL KRIADINSQL HHVPLPESYK
     PEYRADIRAS KEHLKRSLAL AIAAEHKLEK MYKSQMLPQG RSSGGVYDII TVINMLYNSR
     YKLSEYLDIK YVPLEMRGKA TVVVHTLKRI LCVGHGEETH NLLKQLLNNN IRILHILDTH
     DKDDSS