ID   SPF30_DANRE             Reviewed;         237 AA.
AC   Q7ZV80;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Survival of motor neuron-related-splicing factor 30;
DE   AltName: Full=Survival motor neuron domain-containing protein 1;
GN   Name=smndc1; Synonyms=spf30;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in spliceosome assembly (By similarity).
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBUNIT: Associates with spliceosomes. {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:O75940}.
CC       Nucleus, Cajal body {ECO:0000250|UniProtKB:O75940}. Note=Detected in
CC       nuclear speckles containing snRNP and in Cajal (coiled) bodies.
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- DOMAIN: The Tudor domain mediates association with dimethylarginines,
CC       which are common in snRNP proteins. {ECO:0000250|UniProtKB:O75940}.
CC   -!- SIMILARITY: Belongs to the SMN family. {ECO:0000305}.
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DR   EMBL; BC045967; AAH45967.1; -; mRNA.
DR   EMBL; BC067338; AAH67338.1; -; mRNA.
DR   RefSeq; NP_997766.1; NM_212601.2.
DR   AlphaFoldDB; Q7ZV80; -.
DR   SMR; Q7ZV80; -.
DR   STRING; 7955.ENSDARP00000038215; -.
DR   PaxDb; Q7ZV80; -.
DR   PRIDE; Q7ZV80; -.
DR   Ensembl; ENSDART00000031547; ENSDARP00000038215; ENSDARG00000056235.
DR   Ensembl; ENSDART00000180115; ENSDARP00000146987; ENSDARG00000056235.
DR   Ensembl; ENSDART00000193732; ENSDARP00000147770; ENSDARG00000117084.
DR   GeneID; 572679; -.
DR   KEGG; dre:572679; -.
DR   CTD; 10285; -.
DR   ZFIN; ZDB-GENE-030131-614; smndc1.
DR   eggNOG; KOG3026; Eukaryota.
DR   GeneTree; ENSGT00940000153352; -.
DR   HOGENOM; CLU_069491_3_0_1; -.
DR   InParanoid; Q7ZV80; -.
DR   OMA; CMAVWSQ; -.
DR   OrthoDB; 1459016at2759; -.
DR   PhylomeDB; Q7ZV80; -.
DR   TreeFam; TF315413; -.
DR   Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q7ZV80; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000056235; Expressed in mature ovarian follicle and 27 other tissues.
DR   ExpressionAtlas; Q7ZV80; baseline and differential.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR010304; SMN_Tudor.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF06003; SMN; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS50304; TUDOR; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..237
FT                   /note="Survival of motor neuron-related-splicing factor 30"
FT                   /id="PRO_0000347225"
FT   DOMAIN          72..132
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          52..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           142..160
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        52..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..177
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   237 AA;  26940 MW;  15930C3E79212613 CRC64;
     MSEELMKQLS NYKAQLQQVE AALSIDPDNE DLLKLQKDLQ EVIELTKDLL TSQPAEGTTS
     TKSSETVAPS HSWRVGDHCM ATWSQDGQVY EAEIEEIDNE NGTAAITFAG YGNAEVMPLH
     MLKKVEEGRI RDEIDGKPKS KKELQAEQRE YKKKKAQKKV QRMKELEQER EDQKSKWQQF
     NNKAYSKNKK GQVKRSIFAS PESVNGKVGV GTCGIADKPM TQYNDTSKYN VRHLMPQ