SPF30_MOUSE
ID SPF30_MOUSE Reviewed; 238 AA.
AC Q8BGT7; Q4QQL0;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Survival of motor neuron-related-splicing factor 30;
DE AltName: Full=30 kDa splicing factor SMNrp;
DE AltName: Full=SMN-related protein;
DE AltName: Full=Survival motor neuron domain-containing protein 1;
GN Name=Smndc1; Synonyms=Smnr, Spf30;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Clee S.M., Klass D.M., Attie A.D.;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Submandibular gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory epithelium, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in spliceosome assembly (By similarity).
CC {ECO:0000250|UniProtKB:O75940}.
CC -!- SUBUNIT: Associates with spliceosomes. Associates with U4/U5/U6 tri-
CC snRNP and with U2 snRNP (By similarity).
CC {ECO:0000250|UniProtKB:O75940}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:O75940}.
CC Nucleus, Cajal body {ECO:0000250|UniProtKB:O75940}. Note=Detected in
CC nuclear speckles containing snRNP and in Cajal (coiled) bodies.
CC {ECO:0000250|UniProtKB:O75940}.
CC -!- DOMAIN: The Tudor domain mediates association with dimethylarginines,
CC which are common in snRNP proteins. {ECO:0000250|UniProtKB:O75940}.
CC -!- SIMILARITY: Belongs to the SMN family. {ECO:0000305}.
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DR EMBL; DQ479929; ABF48508.1; -; Genomic_DNA.
DR EMBL; AK078834; BAC37414.1; -; mRNA.
DR EMBL; AK090047; BAC41064.1; -; mRNA.
DR EMBL; BC058779; AAH58779.1; -; mRNA.
DR EMBL; BC098223; AAH98223.1; -; mRNA.
DR CCDS; CCDS29902.1; -.
DR RefSeq; NP_766017.1; NM_172429.2.
DR RefSeq; XP_006527504.1; XM_006527441.3.
DR AlphaFoldDB; Q8BGT7; -.
DR BMRB; Q8BGT7; -.
DR SMR; Q8BGT7; -.
DR BioGRID; 218145; 8.
DR IntAct; Q8BGT7; 3.
DR STRING; 10090.ENSMUSP00000025997; -.
DR iPTMnet; Q8BGT7; -.
DR PhosphoSitePlus; Q8BGT7; -.
DR EPD; Q8BGT7; -.
DR jPOST; Q8BGT7; -.
DR MaxQB; Q8BGT7; -.
DR PaxDb; Q8BGT7; -.
DR PeptideAtlas; Q8BGT7; -.
DR PRIDE; Q8BGT7; -.
DR ProteomicsDB; 257348; -.
DR Antibodypedia; 31698; 305 antibodies from 28 providers.
DR DNASU; 76479; -.
DR Ensembl; ENSMUST00000025997; ENSMUSP00000025997; ENSMUSG00000025024.
DR Ensembl; ENSMUST00000237529; ENSMUSP00000157540; ENSMUSG00000025024.
DR GeneID; 76479; -.
DR KEGG; mmu:76479; -.
DR UCSC; uc008hws.1; mouse.
DR CTD; 10285; -.
DR MGI; MGI:1923729; Smndc1.
DR VEuPathDB; HostDB:ENSMUSG00000025024; -.
DR eggNOG; KOG3026; Eukaryota.
DR GeneTree; ENSGT00940000153352; -.
DR HOGENOM; CLU_069491_3_0_1; -.
DR InParanoid; Q8BGT7; -.
DR OMA; CMAVWSQ; -.
DR OrthoDB; 1459016at2759; -.
DR PhylomeDB; Q8BGT7; -.
DR TreeFam; TF315413; -.
DR Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
DR BioGRID-ORCS; 76479; 22 hits in 70 CRISPR screens.
DR ChiTaRS; Smndc1; mouse.
DR PRO; PR:Q8BGT7; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BGT7; protein.
DR Bgee; ENSMUSG00000025024; Expressed in metanephric cortical collecting duct and 267 other tissues.
DR ExpressionAtlas; Q8BGT7; baseline and differential.
DR Genevisible; Q8BGT7; MM.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04508; TUDOR; 1.
DR InterPro; IPR010304; SMN_Tudor.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF06003; SMN; 1.
DR SMART; SM00333; TUDOR; 1.
DR PROSITE; PS50304; TUDOR; 1.
PE 1: Evidence at protein level;
KW Acetylation; Apoptosis; mRNA processing; mRNA splicing; Nucleus;
KW Phosphoprotein; Reference proteome; Spliceosome.
FT CHAIN 1..238
FT /note="Survival of motor neuron-related-splicing factor 30"
FT /id="PRO_0000218909"
FT DOMAIN 72..132
FT /note="Tudor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT MOTIF 142..160
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75940"
FT MOD_RES 219
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75940"
SQ SEQUENCE 238 AA; 26753 MW; 70C59F9AD4D1EF8A CRC64;
MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS
SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAV YGNAEVTPLL
NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ
FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ
