ID   SPF30_RAT               Reviewed;         238 AA.
AC   Q4QQU6; Q4KM88;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Survival of motor neuron-related-splicing factor 30;
DE   AltName: Full=Survival motor neuron domain-containing protein 1;
GN   Name=Smndc1; Synonyms=Spf30;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Placenta, and Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in spliceosome assembly (By similarity).
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBUNIT: Associates with spliceosomes. Associates with U4/U5/U6 tri-
CC       snRNP and with U2 snRNP (By similarity).
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:O75940}.
CC       Nucleus, Cajal body {ECO:0000250|UniProtKB:O75940}. Note=Detected in
CC       nuclear speckles containing snRNP and in Cajal (coiled) bodies.
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4QQU6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4QQU6-2; Sequence=VSP_035075;
CC   -!- DOMAIN: The Tudor domain mediates association with dimethylarginines,
CC       which are common in snRNP proteins. {ECO:0000250|UniProtKB:O75940}.
CC   -!- SIMILARITY: Belongs to the SMN family. {ECO:0000305}.
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DR   EMBL; BC097986; AAH97986.1; -; mRNA.
DR   EMBL; BC098697; AAH98697.1; -; mRNA.
DR   RefSeq; NP_001020571.1; NM_001025400.3. [Q4QQU6-1]
DR   RefSeq; NP_001030311.1; NM_001035234.2. [Q4QQU6-1]
DR   AlphaFoldDB; Q4QQU6; -.
DR   BMRB; Q4QQU6; -.
DR   SMR; Q4QQU6; -.
DR   STRING; 10116.ENSRNOP00000020539; -.
DR   iPTMnet; Q4QQU6; -.
DR   PhosphoSitePlus; Q4QQU6; -.
DR   jPOST; Q4QQU6; -.
DR   PaxDb; Q4QQU6; -.
DR   PRIDE; Q4QQU6; -.
DR   Ensembl; ENSRNOT00000020539; ENSRNOP00000020539; ENSRNOG00000014833. [Q4QQU6-1]
DR   GeneID; 287768; -.
DR   KEGG; rno:287768; -.
DR   CTD; 10285; -.
DR   RGD; 1309151; Smndc1.
DR   eggNOG; KOG3026; Eukaryota.
DR   GeneTree; ENSGT00940000153352; -.
DR   HOGENOM; CLU_2037366_0_0_1; -.
DR   InParanoid; Q4QQU6; -.
DR   OMA; CMAVWSQ; -.
DR   OrthoDB; 1459016at2759; -.
DR   PhylomeDB; Q4QQU6; -.
DR   TreeFam; TF315413; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q4QQU6; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000014833; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; Q4QQU6; baseline and differential.
DR   Genevisible; Q4QQU6; RN.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR010304; SMN_Tudor.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF06003; SMN; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS50304; TUDOR; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Apoptosis; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome.
FT   CHAIN           1..238
FT                   /note="Survival of motor neuron-related-splicing factor 30"
FT                   /id="PRO_0000347224"
FT   DOMAIN          72..132
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   MOTIF           142..160
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         201
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75940"
FT   MOD_RES         219
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O75940"
FT   VAR_SEQ         88..238
FT                   /note="QCYEAEIEEIDEENGTAAITFAVYGNAEVTPLLNLKPVEEGRKAKEDSGNKP
FT                   MSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSI
FT                   FASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ -> HHDIFTGVMRRRSRR
FT                   SMKRTAPLRSPSLSMAMPK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035075"
SQ   SEQUENCE   238 AA;  26783 MW;  65C58A9564DE502F CRC64;
     MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLTS
     SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAV YGNAEVTPLL
     NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ
     FNNRAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ