ID   SPF30_XENTR             Reviewed;         238 AA.
AC   Q6DEY1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Survival of motor neuron-related-splicing factor 30;
DE   AltName: Full=Survival motor neuron domain-containing protein 1;
GN   Name=smndc1; Synonyms=spf30; ORFNames=TGas076b22.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in spliceosome assembly (By similarity).
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBUNIT: Associates with spliceosomes. {ECO:0000250|UniProtKB:O75940}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:O75940}.
CC       Nucleus, Cajal body {ECO:0000250|UniProtKB:O75940}. Note=Detected in
CC       nuclear speckles containing snRNP and in Cajal (coiled) bodies.
CC       {ECO:0000250|UniProtKB:O75940}.
CC   -!- DOMAIN: The Tudor domain mediates association with dimethylarginines,
CC       which are common in snRNP proteins. {ECO:0000250|UniProtKB:O75940}.
CC   -!- SIMILARITY: Belongs to the SMN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR942604; CAJ83801.1; -; mRNA.
DR   EMBL; BC076962; AAH76962.1; -; mRNA.
DR   RefSeq; NP_001006857.1; NM_001006856.2.
DR   AlphaFoldDB; Q6DEY1; -.
DR   SMR; Q6DEY1; -.
DR   STRING; 8364.ENSXETP00000033649; -.
DR   PaxDb; Q6DEY1; -.
DR   DNASU; 448621; -.
DR   GeneID; 448621; -.
DR   KEGG; xtr:448621; -.
DR   CTD; 10285; -.
DR   Xenbase; XB-GENE-491591; smndc1.
DR   eggNOG; KOG3026; Eukaryota.
DR   HOGENOM; CLU_069491_3_0_1; -.
DR   InParanoid; Q6DEY1; -.
DR   OrthoDB; 1459016at2759; -.
DR   Reactome; R-XTR-72163; mRNA Splicing - Major Pathway.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR010304; SMN_Tudor.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF06003; SMN; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS50304; TUDOR; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..238
FT                   /note="Survival of motor neuron-related-splicing factor 30"
FT                   /id="PRO_0000347226"
FT   DOMAIN          72..132
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   MOTIF           142..160
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  26620 MW;  BA1ADC6233F2E805 CRC64;
     MAEDLAKQLA GYKAQLQQVE SALTANGENE DLLKLKKDLQ EVIELTKDLL SSQPSETADD
     ACDDMSASGS QSWKVGEKCM AVWSDDGQWY EAEIEEIDEE NGTAAITFAG YGNAEVTSLL
     NLRPVEEGRK AKEDSGNLPM SKKEMIAAQR EYKKKKALKK AQRIKELEQE REDQKVKWQQ
     FNNKAYSKNK KGQVKRSIFA SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ