SPG17_HUMAN
ID SPG17_HUMAN Reviewed; 2223 AA.
AC Q6Q759; Q8NAZ1; Q9NT21;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Sperm-associated antigen 17;
DE AltName: Full=Projection protein PF6 homolog;
GN Name=SPAG17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15827353; DOI=10.1074/mcp.m400177-mcp200;
RA Zhang Z., Jones B.H., Tang W., Moss S.B., Wei Z., Ho C., Pollack M.,
RA Horowitz E., Bennett J., Baker M.E., Strauss J.F. III;
RT "Dissecting the axoneme interactome: the mammalian orthologue of
RT Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian
RT orthologue of Chlamydomonas PF16.";
RL Mol. Cell. Proteomics 4:914-923(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-922.
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2029-2223.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-1707.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [6]
RP VARIANT SPGF55 GLN-1448, INVOLVEMENT IN SPGF55, AND CHARACTERIZATION OF
RP VARIANT SPGF55 GLN-1448.
RX PubMed=28548327; DOI=10.1111/cge.13059;
RA Xu X., Sha Y.W., Mei L.B., Ji Z.Y., Qiu P.P., Ji H., Li P., Wang T., Li L.;
RT "A familial study of twins with severe asthenozoospermia identified a
RT homozygous SPAG17 mutation by whole-exome sequencing.";
RL Clin. Genet. 93:345-349(2018).
CC -!- FUNCTION: Component of the central pair apparatus of ciliary axonemes.
CC Plays a critical role in the function and structure of motile cilia.
CC May play a role in endochondral bone formation, most likely because of
CC a function in primary cilia of chondrocytes and osteoblasts (By
CC similarity). Essential for normal spermatogenesis and male fertility
CC (By similarity). Required for normal manchette structure, transport of
CC proteins along the manchette microtubules and formation of the sperm
CC head and flagellum (By similarity). Essential for sperm flagellum
CC development and proper assembly of the respiratory motile cilia central
CC pair apparatus, but not the brain ependymal cilia (By similarity).
CC {ECO:0000250|UniProtKB:Q5S003}.
CC -!- SUBUNIT: Interacts (via the C-terminus) with SPAG6; the interaction
CC probably occurs on polymerized microtubules.
CC {ECO:0000250|UniProtKB:Q5S003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5S003}.
CC Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:Q5S003}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome {ECO:0000250|UniProtKB:Q5S003}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q5S003}. Note=Detected in the cytoplasm of round
CC spermatids and in condensing spermatids. Localized to the central pair
CC of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules
CC (By similarity). Localizes to the manchette in elongating spermatids
CC (By similarity). {ECO:0000250|UniProtKB:Q5S003}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Expressed in organs
CC that contain cilia-bearing cells including brain, oviduct, lung, and
CC uterus. {ECO:0000269|PubMed:15827353}.
CC -!- DISEASE: Spermatogenic failure 55 (SPGF55) [MIM:619380]: An autosomal
CC recessive male infertility disorder characterized by
CC asthenozoospermia.Semen analysis shows severely reduced sperm motility.
CC {ECO:0000269|PubMed:28548327}. Note=The disease may be caused by
CC variants affecting the gene represented in this entry.
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DR EMBL; AY555274; AAS66753.1; -; mRNA.
DR EMBL; AL513191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK091816; BAC03753.1; -; mRNA.
DR EMBL; AL137581; CAB70823.1; -; mRNA.
DR CCDS; CCDS899.1; -.
DR PIR; T46291; T46291.
DR RefSeq; NP_996879.1; NM_206996.3.
DR AlphaFoldDB; Q6Q759; -.
DR SMR; Q6Q759; -.
DR BioGRID; 128304; 5.
DR IntAct; Q6Q759; 3.
DR MINT; Q6Q759; -.
DR STRING; 9606.ENSP00000337804; -.
DR iPTMnet; Q6Q759; -.
DR PhosphoSitePlus; Q6Q759; -.
DR BioMuta; SPAG17; -.
DR DMDM; 74749284; -.
DR EPD; Q6Q759; -.
DR jPOST; Q6Q759; -.
DR MassIVE; Q6Q759; -.
DR MaxQB; Q6Q759; -.
DR PaxDb; Q6Q759; -.
DR PeptideAtlas; Q6Q759; -.
DR PRIDE; Q6Q759; -.
DR ProteomicsDB; 67275; -.
DR Antibodypedia; 33897; 36 antibodies from 8 providers.
DR DNASU; 200162; -.
DR Ensembl; ENST00000336338.10; ENSP00000337804.5; ENSG00000155761.14.
DR GeneID; 200162; -.
DR KEGG; hsa:200162; -.
DR MANE-Select; ENST00000336338.10; ENSP00000337804.5; NM_206996.4; NP_996879.1.
DR UCSC; uc001ehk.3; human.
DR CTD; 200162; -.
DR DisGeNET; 200162; -.
DR GeneCards; SPAG17; -.
DR HGNC; HGNC:26620; SPAG17.
DR HPA; ENSG00000155761; Tissue enhanced (choroid plexus, testis).
DR MalaCards; SPAG17; -.
DR MIM; 616554; gene.
DR MIM; 619380; phenotype.
DR neXtProt; NX_Q6Q759; -.
DR OpenTargets; ENSG00000155761; -.
DR Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR PharmGKB; PA142670888; -.
DR VEuPathDB; HostDB:ENSG00000155761; -.
DR eggNOG; ENOG502QSCB; Eukaryota.
DR GeneTree; ENSGT00390000013693; -.
DR HOGENOM; CLU_001433_0_0_1; -.
DR InParanoid; Q6Q759; -.
DR OMA; WDIMVRQ; -.
DR OrthoDB; 32420at2759; -.
DR PhylomeDB; Q6Q759; -.
DR TreeFam; TF328540; -.
DR PathwayCommons; Q6Q759; -.
DR SignaLink; Q6Q759; -.
DR BioGRID-ORCS; 200162; 9 hits in 1077 CRISPR screens.
DR ChiTaRS; SPAG17; human.
DR GenomeRNAi; 200162; -.
DR Pharos; Q6Q759; Tdark.
DR PRO; PR:Q6Q759; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6Q759; protein.
DR Bgee; ENSG00000155761; Expressed in right uterine tube and 110 other tissues.
DR ExpressionAtlas; Q6Q759; baseline and differential.
DR Genevisible; Q6Q759; HS.
DR GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR GO; GO:1990716; C:axonemal central apparatus; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:1904158; P:axonemal central apparatus assembly; IBA:GO_Central.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IBA:GO_Central.
DR GO; GO:1990953; P:intramanchette transport; ISS:UniProtKB.
DR GO; GO:1905198; P:manchette assembly; ISS:UniProtKB.
DR GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR026173; SPAG17.
DR PANTHER; PTHR21963; PTHR21963; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Differentiation; Flagellum;
KW Golgi apparatus; Microtubule; Reference proteome; Spermatogenesis.
FT CHAIN 1..2223
FT /note="Sperm-associated antigen 17"
FT /id="PRO_0000331445"
FT REGION 144..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1962..2008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 266..295
FT /evidence="ECO:0000255"
FT COILED 940..966
FT /evidence="ECO:0000255"
FT COILED 1874..1907
FT /evidence="ECO:0000255"
FT COMPBIAS 739..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..1999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 143
FT /note="R -> Q (in dbSNP:rs12133381)"
FT /id="VAR_042863"
FT VARIANT 158
FT /note="E -> V (in dbSNP:rs17185492)"
FT /id="VAR_042864"
FT VARIANT 1253
FT /note="T -> P (in dbSNP:rs34366834)"
FT /id="VAR_042865"
FT VARIANT 1348
FT /note="P -> L (in dbSNP:rs10923472)"
FT /id="VAR_042866"
FT VARIANT 1448
FT /note="R -> Q (in SPGF55; unknown pathological
FT significance; decreased protein expression in homozygous
FT patient sperm)"
FT /evidence="ECO:0000269|PubMed:28548327"
FT /id="VAR_085965"
FT VARIANT 1707
FT /note="D -> E (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_042867"
FT CONFLICT 52
FT /note="A -> S (in Ref. 3; BAC03753)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="I -> M (in Ref. 3; BAC03753)"
FT /evidence="ECO:0000305"
FT CONFLICT 675
FT /note="D -> G (in Ref. 3; BAC03753)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="L -> P (in Ref. 3; BAC03753)"
FT /evidence="ECO:0000305"
FT CONFLICT 816
FT /note="N -> H (in Ref. 3; BAC03753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2223 AA; 251742 MW; 07C248C5B2A5B561 CRC64;
MAPKKEKGGT VNTSSKIWEP SLIAAQFNQN DWQASIAFVV GNQIEDDLLI QALTVAVQVP
QRKLFSMVSW QDILQQINEI NTLVGSASSK KAKKPVGGNA PLYYEVLTAA KAIMDSGEKL
TLPLIGKLLK FQLLQIKFKD QQRRENEKKV IEDKPKLEKD KGKAKSPKEK KAPSAKPAKG
KGKDQPEANA PVKKTTQLKR RGEDDHTNRY IDDEPDDGAQ HYIIVVGFNN PQLLAIMAEL
GIPITSVIKI SSENYEPLQT HLAAVNQQQE VLLQSEDLEA EKLKKENAIK ELKTFWKYLE
PVLNNEKPET NLFDVARLEY MVKAADFPSD WSDGEMMLKL GTDIFENIAC LMYDILDWKR
QHQHYLESMQ LINVPQVVNE KPVLEAMPTS EAPQPAVPAP GKKKAQYEEP QAPPPVTSVI
TTEVDMRYYN YLLNPIREEF ISVPLILHCM LEQVVATEED LVPPSLREPS PRADGLDHRI
AAHIVSLLPS LCLSEREKKN LHDIFLSEEE NESKAVPKGP LLLNYHDAHA HKKYALQDQK
NFDPVQIEQE MQSKLPLWEF LQFPLPPPWN NTKRLATIHE LMHFCTSDVL SWNEVERAFK
VFTFESLKLS EVDEKGKLKP SGMMCGSDSE MFNIPWDNPA RFAKQIRQQY VMKMNTQEAK
QKADIKIKDR TLFVDQNLSM SVQDNESNRE PSDPSQCDAN NMKHSDLNNL KLSVPDNRQL
LEQESIMKAQ PQHESLEQTT NNEIKDDAVT KADSHEKKPK KMMVEADLED IKKTQQRSLM
DWSFTEHFKP KVLLQVLQEA HKQYRCVDSY YHTQDNSLLL VFHNPMNRQR LHCEYWNIAL
HSNVGFRNYL ELVAKSIQDW ITKEEAIYQE SKMNEKIIRT RAELELKSSA NAKLTSASKI
FSIKESKSNK GISKTEISDQ EKEKEKEKIP FILEGSLKAW KEEQHRLAEE ERLREEKKAE
KKGKEAGKKK GKDNAEKEDS RSLKKKSPYK EKSKEEQVKI QEVTEESPHQ PEPKITYPFH
GYNMGNIPTQ ISGSNYYLYP SDGGQIEVEK TMFEKGPTFI KVRVVKDNHN FMIHLNDPKE
IVKKEEKGDY YLEEEEEGDE EQSLETEVSD AKNKAFSKFG SFSATLENGI CLSISYYGSN
GMAPEDKDPD LETILNIPSA LTPTVVPVIV TVPQSKAKGK IKGKEKPKES LKEEEHPKEE
EKKEEEVEPE PVLQETLDVP TFQSLNVSCP SGLLLTFIGQ ESTGQYVIDE EPTWDIMVRQ
SYPQRVKHYE FYKTVMPPAE QEASRVITSQ GTVVKYMLDG STQILFADGA VSRSPNSGLI
CPPSEMPATP HSGDLMDSIS QQKSETIPSE ITNTKKGKSH KSQSSMAHKG EIHDPPPEAV
QTVTPVEVHI GTWFTTTPEG NRIGTKGLER IADLTPLLSF QATDPVNGTV MTTREDKVVI
VERKDGTRIV DHADGTRITT FYQVYEDQII LPDDQETTEG PRTVTRQVKC MRVESSRYAT
VIANCEDSSC CATFGDGTTI IAKPQGTYQV LPPNTGSLYI DKDCSAVYCH ESSSNIYYPF
QKREQLRAGR YIMRHTSEVI CEVLDPEGNT FQVMADGSIS TILPEKKLED DLNEKTEGYD
SLSSMHLEKN HQQIYGEHVP RFFVMYADGS GMELLRDSDI EEYLSLAYKE SNTVVLQEPV
QEQPGTLTIT VLRPFHEASP WQVKKEDTIV PPNLRSRSWE TFPSVEKKTP GPPFGTQIWK
GLCIESKQLV SAPGAILKSP SVLQMRQFIQ HEVIKNEVKL RLQVSLKDYI NYILKKEDEL
QEMMVKDSRT EEERGNAADL LKLVMSFPKM EETTKSHVTE VAAHLTDLFK QSLATPPKCP
PDTFGKDFFE KTWRHTASSK RWKEKIDKTR KEIETTQNYL MDIKNRIIPP FFKSELNQLY
QSQYNHLDSL SKKLPSFTKK NEDANETAVQ DTSDLNLDFK PHKVSEQKSS SVPSLPKPEI
SADKKDFTAQ NQTENLTKSP EEAESYEPVK IPTQSLLQDV AGQTRKEKVK LPHYLLSSKP
KSQPLAKVQD SVGGKVNTSS VASAAINNAK SSLFGFHLLP SSVKFGVLKE GHTYATVVKL
KNVGVDFCRF KVKQPPPSTG LKVTYKPGPV AAGMQTELNI ELFATAVGED GAKGSAHISH
NIEIMTEHEV LFLPVEATVL TSSNYDKRPK DFPQGKENPM VQRTSTIYSS TLGVFMSRKV
SPH
