SPG1_SCHPO
ID SPG1_SCHPO Reviewed; 198 AA.
AC P87027; O14312;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Septum-promoting GTP-binding protein 1;
DE AltName: Full=GTPase spg1;
DE AltName: Full=Sid3 protein;
GN Name=spg1; Synonyms=sid3; ORFNames=SPAC1565.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH CDC7.
RX PubMed=9203579; DOI=10.1101/gad.11.12.1519;
RA Schmidt S., Sohrmann M., Hofmann K., Woollard A., Simanis V.;
RT "The Spg1p GTPase is an essential, dosage-dependent inducer of septum
RT formation in Schizosaccharomyces pombe.";
RL Genes Dev. 11:1519-1534(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9649519; DOI=10.1093/genetics/149.3.1265;
RA Balasubramanian M.K., McCollum D., Chang L., Wong K.C.Y., Naqvi N.I.,
RA He X., Sazer S., Gould K.L.;
RT "Isolation and characterization of new fission yeast cytokinesis mutants.";
RL Genetics 149:1265-1275(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP INTERACTION WITH CDC11.
RX PubMed=15062098; DOI=10.1016/j.cub.2004.03.036;
RA Morrell J.L., Tomlin G.C., Rajagopalan S., Venkatram S., Feoktistova A.S.,
RA Tasto J.J., Mehta S., Jennings J.L., Link A., Balasubramanian M.K.,
RA Gould K.L.;
RT "Sid4p-Cdc11p assembles the septation initiation network and its regulators
RT at the S. pombe SPB.";
RL Curr. Biol. 14:579-584(2004).
CC -!- FUNCTION: GTP-binding protein essential for the induction of septum
CC formation at G2 and pre-START stages of mitosis. Acts via the cdc7
CC protein kinase pathway. {ECO:0000269|PubMed:9203579}.
CC -!- SUBUNIT: Interacts with cdc7 and cdc11. {ECO:0000269|PubMed:15062098,
CC ECO:0000269|PubMed:9203579}.
CC -!- INTERACTION:
CC P87027; Q10951: byr4; NbExp=7; IntAct=EBI-1999803, EBI-1997311;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y12314; CAA72985.1; -; Genomic_DNA.
DR EMBL; AJ001587; CAA04846.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB99273.1; -; Genomic_DNA.
DR PIR; T45541; T45541.
DR RefSeq; NP_593285.1; NM_001018715.2.
DR AlphaFoldDB; P87027; -.
DR SMR; P87027; -.
DR BioGRID; 279211; 44.
DR IntAct; P87027; 2.
DR STRING; 4896.SPAC1565.06c.1; -.
DR iPTMnet; P87027; -.
DR MaxQB; P87027; -.
DR PaxDb; P87027; -.
DR EnsemblFungi; SPAC1565.06c.1; SPAC1565.06c.1:pep; SPAC1565.06c.
DR GeneID; 2542761; -.
DR KEGG; spo:SPAC1565.06c; -.
DR PomBase; SPAC1565.06c; spg1.
DR VEuPathDB; FungiDB:SPAC1565.06c; -.
DR eggNOG; KOG1673; Eukaryota.
DR HOGENOM; CLU_041217_0_2_1; -.
DR InParanoid; P87027; -.
DR OMA; KIFKIVI; -.
DR PhylomeDB; P87027; -.
DR PRO; PR:P87027; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0005816; C:spindle pole body; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IDA:PomBase.
DR GO; GO:0003924; F:GTPase activity; IDA:PomBase.
DR GO; GO:0035591; F:signaling adaptor activity; IDA:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0140281; P:positive regulation of mitotic division septum assembly; IMP:PomBase.
DR GO; GO:0031028; P:septation initiation signaling; IGI:PomBase.
DR CDD; cd04128; Spg1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR017231; Small_GTPase_Tem1/Spg1.
DR PANTHER; PTHR47978:SF24; PTHR47978:SF24; 1.
DR Pfam; PF00071; Ras; 1.
DR PIRSF; PIRSF037527; Small_GTPase_Tem1; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; GTP-binding; Mitosis; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..198
FT /note="Septum-promoting GTP-binding protein 1"
FT /id="PRO_0000122465"
FT REGION 6..198
FT /note="Small GTPase-like"
FT BINDING 17..24
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 65..69
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 122..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 43
FT /note="L -> LV (in Ref. 2; CAA04846)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 198 AA; 22543 MW; F9FFD08A5BF36316 CRC64;
MADARKNNVT IKVGMIGDSS IGKTSLMVTY VQGSFDEEST QTLGVNFMEK TISIRNTEIT
FSIWDLGGQR EFVNMLPMVC NDAVAILFMF DLSRKSTLNS IKEWYRQARG FNKTAVPILI
GTKYDHFMTF PREDQEEITK QARRYAKAMK ASLVFCSTSH SINVQKIFKI VLAKVFDLKC
TIPEIKNVGD PILEYIDR
