SPG1_YEAST
ID SPG1_YEAST Reviewed; 95 AA.
AC P50088; D6VV16;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Stationary phase gene 1 protein;
GN Name=SPG1; OrderedLocusNames=YGR236C; ORFNames=G8578;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8701610;
RX DOI=10.1002/(sici)1097-0061(19960330)12:4<385::aid-yea910>3.0.co;2-g;
RA van der Aart Q.J.M., Kleine K., Steensma H.Y.;
RT "Sequence analysis of the 43 kb CRM1-YLM9-PET54-DIE2-SMI1-PHO81-YHB4-PFK1
RT region from the right arm of Saccharomyces cerevisiae chromosome VII.";
RL Yeast 12:385-390(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP IDENTIFICATION OF FRAMESHIFT.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [6]
RP INDUCTION.
RX PubMed=15456898; DOI=10.1091/mbc.e03-11-0856;
RA Martinez M.J., Roy S., Archuletta A.B., Wentzell P.D., Anna-Arriola S.S.,
RA Rodriguez A.L., Aragon A.D., Quinones G.A., Allen C., Werner-Washburne M.;
RT "Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae:
RT gene expression and identification of novel essential genes.";
RL Mol. Biol. Cell 15:5295-5305(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Abundant in stationary phase (G0) cells. mRNA levels rapidly
CC decrease upon exit from G0. {ECO:0000269|PubMed:15456898}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA61186.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA97264.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X87941; CAA61186.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z73021; CAA97264.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006941; DAA08327.1; -; Genomic_DNA.
DR PIR; S57701; S57701.
DR RefSeq; NP_011752.4; NM_001181365.3.
DR AlphaFoldDB; P50088; -.
DR SMR; P50088; -.
DR BioGRID; 33488; 15.
DR DIP; DIP-4078N; -.
DR STRING; 4932.YGR236C; -.
DR PaxDb; P50088; -.
DR EnsemblFungi; YGR236C_mRNA; YGR236C; YGR236C.
DR GeneID; 853151; -.
DR KEGG; sce:YGR236C; -.
DR SGD; S000003468; SPG1.
DR VEuPathDB; FungiDB:YGR236C; -.
DR eggNOG; ENOG502SCND; Eukaryota.
DR HOGENOM; CLU_183906_0_0_1; -.
DR InParanoid; P50088; -.
DR OMA; ENIAHKP; -.
DR BioCyc; YEAST:G3O-30914-MON; -.
DR PRO; PR:P50088; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P50088; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..95
FT /note="Stationary phase gene 1 protein"
FT /id="PRO_0000202853"
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 95 AA; 10545 MW; 442619D6BDA36AFC CRC64;
MKLDSGIYSE AQRVVRTPKF RYIMLGLVGA AVVPTAYMRR GYTVPAHSLD NINGVDTTKA
SVMGTEQRAA MTKGKSLQEM MDDDEVTYLM FSSIM
