ID   SPG21_BOVIN             Reviewed;         308 AA.
AC   Q8MJJ1; Q17QJ9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=SPG21;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retinal pigment epithelium;
RX   PubMed=12131876;
RA   Sharma S., Chang J.T., Della N.G., Campochiaro P.A., Zack D.J.;
RT   "Identification of novel bovine RPE and retinal genes by subtractive
RT   hybridization.";
RL   Mol. Vis. 8:251-258(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC       dependent T-cell activation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AF451182; AAM76998.1; -; mRNA.
DR   EMBL; BC118320; AAI18321.1; -; mRNA.
DR   RefSeq; NP_991341.1; NM_205772.1.
DR   AlphaFoldDB; Q8MJJ1; -.
DR   SMR; Q8MJJ1; -.
DR   STRING; 9913.ENSBTAP00000015332; -.
DR   ESTHER; bovin-SPG21; Maspardin-ACP33-SPG21_like.
DR   PaxDb; Q8MJJ1; -.
DR   PRIDE; Q8MJJ1; -.
DR   Ensembl; ENSBTAT00000015332; ENSBTAP00000015332; ENSBTAG00000011540.
DR   GeneID; 404069; -.
DR   KEGG; bta:404069; -.
DR   CTD; 51324; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011540; -.
DR   VGNC; VGNC:35208; SPG21.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   GeneTree; ENSGT00390000007857; -.
DR   HOGENOM; CLU_052260_0_0_1; -.
DR   InParanoid; Q8MJJ1; -.
DR   OMA; SVDFMVE; -.
DR   OrthoDB; 694393at2759; -.
DR   TreeFam; TF105253; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000011540; Expressed in oocyte and 104 other tissues.
DR   ExpressionAtlas; Q8MJJ1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..308
FT                   /note="Maspardin"
FT                   /id="PRO_0000227979"
FT   DOMAIN          87..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD8"
SQ   SEQUENCE   308 AA;  35006 MW;  783E9FEE291AA499 CRC64;
     MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR NIRCPLIFLP PVSGTADVFF
     RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVHS LILCNSFSDT SIFNQTWTAS SFWLMPSFML KKIVLGNFSS GPVDPMMADA
     IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK
     LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS
     LGISQEEQ