ID   SPG21_DANRE             Reviewed;         311 AA.
AC   Q6PC62;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=spg21;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AY394947; AAQ94574.1; -; mRNA.
DR   EMBL; BC059461; AAH59461.1; -; mRNA.
DR   RefSeq; NP_998560.1; NM_213395.1.
DR   AlphaFoldDB; Q6PC62; -.
DR   SMR; Q6PC62; -.
DR   STRING; 7955.ENSDARP00000109573; -.
DR   ESTHER; danre-SPG21; Maspardin-ACP33-SPG21_like.
DR   PaxDb; Q6PC62; -.
DR   GeneID; 406704; -.
DR   KEGG; dre:406704; -.
DR   CTD; 51324; -.
DR   ZFIN; ZDB-GENE-040426-2722; spg21.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   InParanoid; Q6PC62; -.
DR   OrthoDB; 818498at2759; -.
DR   PhylomeDB; Q6PC62; -.
DR   PRO; PR:Q6PC62; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Maspardin"
FT                   /id="PRO_0000227985"
FT   DOMAIN          86..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   311 AA;  35571 MW;  2C21BC65D37C8E9C CRC64;
     MEEIRVSPDY NWFRSTVPLK RIIVDDDDSK VWSLYDAGPK SIRCPIIFLP PVSGTAEVFF
     QQVLALSGWG YRVISLQYPV YWDLLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     VTYKSPRVHS LVLCNSFSDT SIFNQTWTAN SFWLMPSFML KKIVLGNFAK GPVDPKMADA
     IDFMVDRLES LNQSELASRL TLNCQNSYVE PHKIKDIAVT IMDVFDQSAL SQEAKEEMYK
     LYPNARRAHL KTGGNFPYLC RSAEVNLYIQ IHLRQFHGTR YAAISPEMVS AEELEVQRTH
     LSNNSESEDE S