ID   SPG21_MACFA             Reviewed;         308 AA.
AC   Q4R5H6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=SPG21; ORFNames=QflA-14453;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC       dependent T-cell activation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AB169567; BAE01649.1; -; mRNA.
DR   RefSeq; NP_001270552.1; NM_001283623.1.
DR   AlphaFoldDB; Q4R5H6; -.
DR   SMR; Q4R5H6; -.
DR   STRING; 9541.XP_005559859.1; -.
DR   ESTHER; macfa-SPG21; Maspardin-ACP33-SPG21_like.
DR   GeneID; 101866571; -.
DR   CTD; 51324; -.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..308
FT                   /note="Maspardin"
FT                   /id="PRO_0000227981"
FT   DOMAIN          87..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  34973 MW;  3BDD0A07F89981C2 CRC64;
     MGEVKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
     RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
     IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK
     LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS
     LGINQEEQ