ID   SPG21_PONAB             Reviewed;         308 AA.
AC   Q5RES2; Q5R7M9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=SPG21;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC       dependent T-cell activation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; CR857444; CAH89735.1; -; mRNA.
DR   EMBL; CR860085; CAH92231.1; -; mRNA.
DR   RefSeq; NP_001127527.1; NM_001134055.1.
DR   AlphaFoldDB; Q5RES2; -.
DR   SMR; Q5RES2; -.
DR   STRING; 9601.ENSPPYP00000024383; -.
DR   ESTHER; ponab-SPG21; Maspardin-ACP33-SPG21_like.
DR   GeneID; 100174603; -.
DR   KEGG; pon:100174603; -.
DR   CTD; 51324; -.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   InParanoid; Q5RES2; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..308
FT                   /note="Maspardin"
FT                   /id="PRO_0000227983"
FT   DOMAIN          87..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         304
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD8"
FT   CONFLICT        226
FT                   /note="G -> D (in Ref. 1; CAH92231)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        233
FT                   /note="E -> G (in Ref. 1; CAH92231)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   308 AA;  34902 MW;  40C4F5DB4E7F8381 CRC64;
     MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
     RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
     IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFGQSAL STEAKEEMYK
     LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS
     LGISQEEQ