ID   SPG21_RAT               Reviewed;         261 AA.
AC   Q5XIC4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=Spg21;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC       dependent T-cell activation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; BC083760; AAH83760.1; -; mRNA.
DR   RefSeq; NP_001006988.1; NM_001006987.1.
DR   AlphaFoldDB; Q5XIC4; -.
DR   SMR; Q5XIC4; -.
DR   STRING; 10116.ENSRNOP00000039361; -.
DR   ESTHER; ratno-SPG21; Maspardin-ACP33-SPG21_like.
DR   iPTMnet; Q5XIC4; -.
DR   PhosphoSitePlus; Q5XIC4; -.
DR   jPOST; Q5XIC4; -.
DR   PaxDb; Q5XIC4; -.
DR   DNASU; 300791; -.
DR   Ensembl; ENSRNOT00000051504; ENSRNOP00000039361; ENSRNOG00000015019.
DR   GeneID; 300791; -.
DR   KEGG; rno:300791; -.
DR   UCSC; RGD:1359141; rat.
DR   CTD; 51324; -.
DR   RGD; 1359141; Spg21.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   GeneTree; ENSGT00390000007857; -.
DR   InParanoid; Q5XIC4; -.
DR   PRO; PR:Q5XIC4; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000015019; Expressed in lung and 19 other tissues.
DR   ExpressionAtlas; Q5XIC4; baseline and differential.
DR   Genevisible; Q5XIC4; RN.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..261
FT                   /note="Maspardin"
FT                   /id="PRO_0000227984"
FT   DOMAIN          87..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         257
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NZD8"
SQ   SEQUENCE   261 AA;  29576 MW;  000E08692F45E1C0 CRC64;
     MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
     QQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVHS LILCNAFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
     IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDIHLLQFH GTKYAAIDPS
     VVSAEELDVQ KGQLDLSQEE P