ID   SPG21_XENLA             Reviewed;         310 AA.
AC   Q5FVD6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Maspardin;
DE   AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN   Name=spg21;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; BC090056; AAH90056.1; -; mRNA.
DR   RefSeq; NP_001089266.1; NM_001095797.1.
DR   AlphaFoldDB; Q5FVD6; -.
DR   SMR; Q5FVD6; -.
DR   ESTHER; xenla-SPG21; Maspardin-ACP33-SPG21_like.
DR   DNASU; 734314; -.
DR   GeneID; 734314; -.
DR   KEGG; xla:734314; -.
DR   CTD; 734314; -.
DR   Xenbase; XB-GENE-6251470; spg21.S.
DR   OMA; DYCAVPQ; -.
DR   OrthoDB; 818498at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 734314; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR   GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; PTHR15913; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..310
FT                   /note="Maspardin"
FT                   /id="PRO_0000227986"
FT   DOMAIN          87..159
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   310 AA;  35285 MW;  7ECC40DB9513CB2D CRC64;
     MGAIKISPDY NWFRSTVPLK RIIVDDDDSK VWSLYDAGPR SVRCPIIYLP PVSGTADVFF
     HQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDDLHL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVQS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKILLGNFSS GPVDPVMADA
     IDFMVDRLES LNQSELASRL TLNCQNAYVE PHKIRDTAVT IMDVFDQSAL SMDAKEEMYK
     LYPNARRAHL KTGGNFPYLC RSAEVSLYVQ IHLRQFHGTR YAAIDPAMVS EEELEVQKSF
     PQTTVEAEES