ID   SPH1_HALSI              Reviewed;         629 AA.
AC   O07116;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Smc-like protein Sph1;
GN   Name=sph1; Synonyms=hp71;
OS   Halobacterium salinarum (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=2242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND
RP   OVEREXPRESSION.
RC   STRAIN=DSM 670;
RX   PubMed=9396829; DOI=10.1007/s002030050534;
RA   Ruepp A., Wanner G., Soppa J.;
RT   "A 71-kDa protein from Halobacterium salinarium belongs to a ubiquitous P-
RT   loop ATPase superfamily.";
RL   Arch. Microbiol. 169:1-9(1998).
RN   [2]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=DSM 670;
RX   PubMed=12406217; DOI=10.1046/j.1365-2958.2002.03181.x;
RA   Herrmann U., Soppa J.;
RT   "Cell cycle-dependent expression of an essential SMC-like protein and
RT   dynamic chromosome localization in the archaeon Halobacterium salinarum.";
RL   Mol. Microbiol. 46:395-409(2002).
CC   -!- FUNCTION: May play a role in a late step of replication.
CC       {ECO:0000269|PubMed:12406217}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9396829}.
CC   -!- DEVELOPMENTAL STAGE: Protein level is high around the time of septum
CC       formation, but a basal protein level is present throughout the whole
CC       cell cycle. {ECO:0000269|PubMed:12406217}.
CC   -!- INDUCTION: Transcription is regulated in a cell cycle-dependent manner,
CC       with maximal expression around the time of septum formation.
CC       {ECO:0000269|PubMed:12406217}.
CC   -!- MISCELLANEOUS: Overexpression results in modifications of cell
CC       morphology from rods to extended rods.
CC   -!- SIMILARITY: Belongs to the Sph1/Sph2 family. {ECO:0000305}.
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DR   EMBL; Y13615; CAA73936.1; -; Genomic_DNA.
DR   PIR; T44607; T44607.
DR   AlphaFoldDB; O07116; -.
DR   SMR; O07116; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm.
FT   CHAIN           1..629
FT                   /note="Smc-like protein Sph1"
FT                   /id="PRO_0000409224"
FT   COILED          139..282
FT                   /evidence="ECO:0000255"
FT   COILED          318..487
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   629 AA;  70913 MW;  1E87D68EB859AAFC CRC64;
     MWNVDVTCIG GIRSGEATLR PGPNIVQASN FQGKSSFLAA IQTAIGTTGL LTEDHPLMEN
     EDDGKVTLET DEETYTVSLT RATDSDEPAI SRSGTPYLTR DQDQIAARLF AVLGEDNPIR
     AAVREENQER LTELLKKPLE TENIDLRIEP LQREIKELED EVAAAEAASA DLPAAQQKVT
     RLQGELRDLN ETRDELERKV DEETDQRALR DELTAKQSDL EREEARLERL ENQVDRRKAQ
     LDDKEAALES LDIPDSPTAE ADIAEKQTRI DELAVKIDLL DDLHRSTKAI IDEGEIDLIT
     DVERTLSGDT FSCFVCGAET TAEAVTERLN EISDRQESLR EQRATLTEEV TQMQQRTREI
     ESKRQQKAEL EDEIKRLRVD IQEDQHEVRS IEATIEELQA EIEQREAEYE AAEKAGESHS
     AELKTIQQKI GSTETKLDRA QAELERIEAE LQKRNDRQEQ LETKRDELET LRQRRKQKYN
     ELVNQFDAAM ADIIGRFAPG FDGAYLDQKT DANDTVGFEI NLARDGHTTD LDTLSEGERE
     LVGIVTALAG YRTFSVGDRV PCILLDGIGQ LAAEHIRHMI EYLENTAEIL VTTAYPEAGS
     FDGETVSPEH WDVISHETAQ SRDHPQITN