ID   SPH_STRP1               Reviewed;         376 AA.
AC   P50470;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Immunoglobulin G-binding protein H;
DE            Short=IgG-binding protein H;
DE   Flags: Precursor;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 42-51.
RC   STRAIN=AP1 / 40/58 / Serotype M1;
RX   PubMed=2332638;
RA   Gomi H., Hozumi T., Hattori S., Tagawa C., Kishimoto F., Bjoerck L.;
RT   "The gene sequence and some properties of protein H. A novel IgG-binding
RT   protein.";
RL   J. Immunol. 144:4046-4052(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- SIMILARITY: Belongs to the M protein family. {ECO:0000305}.
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DR   EMBL; M29398; AAA26963.1; -; Genomic_DNA.
DR   PIR; A43528; A43528.
DR   AlphaFoldDB; P50470; -.
DR   SMR; P50470; -.
DR   STRING; 1314.HKU360_01834; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0019864; F:IgG binding; IEA:UniProtKB-KW.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR019950; M_anchor.
DR   InterPro; IPR003345; M_repeat.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF02370; M; 5.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   PRINTS; PR00015; GPOSANCHOR.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Direct protein sequencing; IgG-binding protein;
KW   Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000269|PubMed:2332638"
FT   CHAIN           42..345
FT                   /note="Immunoglobulin G-binding protein H"
FT                   /id="PRO_0000005661"
FT   PROPEP          346..376
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005662"
FT   REPEAT          159..199
FT                   /note="C-1"
FT   REPEAT          200..241
FT                   /note="C-2"
FT   REPEAT          242..283
FT                   /note="C-3"
FT   REGION          69..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..283
FT                   /note="3 X repeats, type C"
FT   REGION          292..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           342..346
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        69..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         345
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   376 AA;  42501 MW;  F3BC76EBFDDFC317 CRC64;
     MTRQQTKKNY SLRKLKTGTA SVAVALTVLG AGFANQTTVK AEGAKIDWQE EYKKLDEDNA
     KLVEVVETTS LENEKLKSEN EENKKNLDKL SKENQGKLEK LELDYLKKLD HEHKEHQKEQ
     QEQEERQKNQ EQLERKYQRE VEKRYQEQLQ KQQQLETEKQ ISEASRKSLS RDLEASRAAK
     KDLEAEHQKL EAEHQKLKED KQISDASRQG LSRDLEASRA AKKELEANHQ KLEAEHQKLK
     EDKQISDASR QGLSRDLEAS RAAKKELEAN HQKLEAEAKA LKEQLAKQAE ELAKLRAGKA
     SDSQTPDTKP GNKAVPGKGQ APQAGTKPNQ NKAPMKETKR QLPSTGETAN PFFTAAALTV
     MATAGVAAVV KRKEEN