SPI1_CAEEL
ID SPI1_CAEEL Reviewed; 100 AA.
AC Q8MPZ7;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Serine protease inhibitor 1 protein {ECO:0000312|WormBase:R10H1.4};
DE AltName: Full=Inhibitor of serine protease-like protein 1;
DE AltName: Full=Putative trypsin inhibitor isl-1;
DE Flags: Precursor;
GN Name=spi-1 {ECO:0000312|WormBase:R10H1.4};
GN Synonyms=isl-1 {ECO:0000312|WormBase:R10H1.4};
GN ORFNames=R10H1.4 {ECO:0000312|WormBase:R10H1.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; FO080701; CCD65951.1; -; Genomic_DNA.
DR RefSeq; NP_872050.1; NM_182250.3.
DR AlphaFoldDB; Q8MPZ7; -.
DR SMR; Q8MPZ7; -.
DR STRING; 6239.R10H1.4; -.
DR PaxDb; Q8MPZ7; -.
DR PeptideAtlas; Q8MPZ7; -.
DR EnsemblMetazoa; R10H1.4.1; R10H1.4.1; WBGene00023416.
DR EnsemblMetazoa; R10H1.4.2; R10H1.4.2; WBGene00023416.
DR GeneID; 174219; -.
DR KEGG; cel:CELE_R10H1.4; -.
DR UCSC; R10H1.4; c. elegans.
DR CTD; 174219; -.
DR WormBase; R10H1.4; CE31821; WBGene00023416; spi-1.
DR eggNOG; ENOG502TIBF; Eukaryota.
DR HOGENOM; CLU_2308529_0_0_1; -.
DR InParanoid; Q8MPZ7; -.
DR OMA; VETHSCK; -.
DR OrthoDB; 1625853at2759; -.
DR PRO; PR:Q8MPZ7; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00023416; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR SUPFAM; SSF57567; SSF57567; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..100
FT /note="Serine protease inhibitor 1 protein"
FT /evidence="ECO:0000305"
FT /id="PRO_0000034309"
FT DOMAIN 42..93
FT /note="TIL"
FT DISULFID 42..74
FT /evidence="ECO:0000250"
FT DISULFID 51..69
FT /evidence="ECO:0000250"
FT DISULFID 54..65
FT /evidence="ECO:0000250"
FT DISULFID 58..93
FT /evidence="ECO:0000250"
FT DISULFID 76..90
FT /evidence="ECO:0000250"
SQ SEQUENCE 100 AA; 11366 MW; A7A6F5A3ADC503F3 CRC64;
MKHLLIVSLV FVTIIWKIEC ETDMYDDSSI VKTEETEEVK PCGLNEVWMV CSSCEEECGK
TPQPCPRICQ PARCQCPAHK GYRRDGQGNC IFCHDSVPKL
