ID   SPI1_RABPU              Reviewed;         357 AA.
AC   P42928; Q6RZT6;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   12-AUG-2020, entry version 76.
DE   RecName: Full=Serine proteinase inhibitor 1;
DE            Short=Serp-1;
DE            Short=Serpin-1;
GN   Name=SPI-1; OrderedLocusNames=RPXV005;
OS   Rabbitpox virus (strain Utrecht) (RPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=45417;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8009842; DOI=10.1006/viro.1994.1347;
RA   Ali A.N., Turner P.C., Brooks M.A., Moyer R.W.;
RT   "The SPI-1 gene of rabbitpox virus determines host range and is required
RT   for hemorrhagic pock formation.";
RL   Virology 202:305-314(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16227218; DOI=10.1099/vir.0.81331-0;
RA   Li G., Chen N., Roper R.L., Feng Z., Hunter A.L., Danila M.,
RA   Lefkowitz E.J., Buller R.M.L., Upton C.;
RT   "Complete coding sequences of the rabbitpox virus genome.";
RL   J. Gen. Virol. 86:2969-2977(2005).
CC   -!- FUNCTION: This viral protein may be involved in the regulation of the
CC       complement cascade. Involved in red pock formation.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serpin family. Poxviruses subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U07766; AAA19159.1; -; Genomic_DNA.
DR   EMBL; AY484669; AAS49718.1; -; Genomic_DNA.
DR   SMR; P42928; -.
DR   MEROPS; I04.028; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Protease inhibitor; Serine protease inhibitor.
FT   CHAIN           1..357
FT                   /note="Serine proteinase inhibitor 1"
FT                   /id="PRO_0000094140"
FT   SITE            322..323
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   357 AA;  40906 MW;  A73944636EF42A72 CRC64;
     MDIFKELILK HPDENVLISP VSILSTLSIL NHGAAGSTAE QLSKYIENVN ENTPDDKKDD
     NNDMDVDIPY CATLATANKI YCSDSIEFHA SFLQKIKDGF QTVNFNNANQ TKELINEWVK
     TMTNGKINSL LTSPLSINTR MTVVSAVHFK AMWKYPFSKH LTYTDKFYIS KNIVTSVDMM
     VSTENDLQYV HINELFGGFS IIDIPYEGNS SMVIILPDDI EGIYNIEKNI TDEKFKKWCG
     MLSTKSIDLY MPKFKVEMTE PYNLVPILEN LGLTNIFGYY ADFSKMCNET ITVEKFLHTT
     FIDVNEEYTE ASAVTGVFMT NFSMVYRTKV YINHPFMYMI KDNTGRILFI GKYCYPQ